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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gas8Gt(CH0760)Wtsi
gene trap CH0760, Wellcome Trust Sanger Institute
MGI:3870680
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gas8Gt(CH0760)Wtsi/Gas8Gt(CH0760)Wtsi involves: 129P2/OlaHsd * C57BL/6 MGI:5803879
ht2
Gas8Gt(CH0760)Wtsi/Gas8em1Bky involves: 129P2/OlaHsd * C57BL/6 MGI:5803880


Genotype
MGI:5803879
hm1
Allelic
Composition
Gas8Gt(CH0760)Wtsi/Gas8Gt(CH0760)Wtsi
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gas8Gt(CH0760)Wtsi mutation (0 available); any Gas8 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die by P14 with few living mice at P21

growth/size/body
• in 6 of 16 live born mice
• in 6 of 16 live born mice based on stomach and heart position

respiratory system
• broken doublet rings and disorganized arrangement of microtubule doublets in some cilia with dyskinesia
• short cilia

nervous system
• severe

cellular

digestive/alimentary system
• in 6 of 16 live born mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
primary ciliary dyskinesia 33 DOID:0110619 OMIM:616726
J:234173




Genotype
MGI:5803880
ht2
Allelic
Composition
Gas8Gt(CH0760)Wtsi/Gas8em1Bky
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gas8em1Bky mutation (0 available); any Gas8 mutation (10 available)
Gas8Gt(CH0760)Wtsi mutation (0 available); any Gas8 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mild to moderate at 10 weeks of age

growth/size/body
N
• mice do not exhibit laterality defects

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
primary ciliary dyskinesia 33 DOID:0110619 OMIM:616726
J:234173





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory