Phenotypes associated with this allele

• Allele Symbol: Mcm9^{Gt(AW0655)Wtsi}
• Allele Name: gene trap AW0655, Wellcome Trust Sanger Institute
• Allele ID: MGI:3857270
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mcm9^Gt(AW0655)Wtsi/Mcm9^Gt(AW0655)Wtsi	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:5295417
ht2	Mcm9^Gt(AW0655)Wtsi/Mcm9^Gt(XG743)Byg	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:5295419

Genotype
MGI:5295417

hm1

• Allelic Composition: Mcm9^{Gt(AW0655)Wtsi}/Mcm9^{Gt(AW0655)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal spermatogonia morphology ( J:177420 )

♂ • some (about 5%) seminiferous tubules lack spermatogonia

decreased male germ cell number ( J:177420 )

♂ • progressive germ cell depletion

oligozoospermia ( J:177420 )

♂ • a 67% decrease in epididymal sperm concentration at 12 weeks of age

♂ • despite the decrease in sperm concentration, males are fertile

mortality/aging

mortality/aging ( J:177420 )

N • viable

premature ovarian failure ( J:177420 )

♀

liver/biliary system

increased hepatocellular carcinoma incidence ( J:177420 )

• increased incidence in males at 1 year of age and all affected mice have multiple hepatocellular carcinomas

reproductive system

abnormal spermatogonia morphology ( J:177420 )

♂ • some (about 5%) seminiferous tubules lack spermatogonia

decreased male germ cell number ( J:177420 )

♂ • progressive germ cell depletion

oligozoospermia ( J:177420 )

♂ • a 67% decrease in epididymal sperm concentration at 12 weeks of age

♂ • despite the decrease in sperm concentration, males are fertile

ovary hyperplasia ( J:177420 )

♀

abnormal seminiferous tubule morphology ( J:177420 )

♂ • some tubules show progressive germ cell depletion, lack spermatogonia or contain a cohort of spermatocytes arrested in meiosis

small testis ( J:177420 )

♂ • detected at puberty and the difference in size compared to controls increases over time

increased ovary tumor incidence ( J:177420 )

♀ • at 1 year of age

premature ovarian failure ( J:177420 )

♀

arrest of male meiosis ( J:177420 )

♂ • about 5% of seminiferous tubules contain a cohort of spermatocytes arrested in meiosis

female infertility ( J:177420 )

♀ • most females are infertile

neoplasm

increased tumor incidence ( J:177420 )

• all males develop tumors by 1 year of age

increased ovary tumor incidence ( J:177420 )

♀ • at 1 year of age

increased hepatocellular carcinoma incidence ( J:177420 )

• increased incidence in males at 1 year of age and all affected mice have multiple hepatocellular carcinomas

increased adenoma incidence ( J:177420 )

• tubulostromal adenomas

endocrine/exocrine glands

ovary hyperplasia ( J:177420 )

♀

abnormal seminiferous tubule morphology ( J:177420 )

♂ • some tubules show progressive germ cell depletion, lack spermatogonia or contain a cohort of spermatocytes arrested in meiosis

small testis ( J:177420 )

♂ • detected at puberty and the difference in size compared to controls increases over time

increased ovary tumor incidence ( J:177420 )

♀ • at 1 year of age

premature ovarian failure ( J:177420 )

♀

growth/size/body

ovary hyperplasia ( J:177420 )

♀

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:177420

Genotype
MGI:5295419

ht2

• Allelic Composition: Mcm9^{Gt(AW0655)Wtsi}/Mcm9^Gt(XG743)Byg
• Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

cellular

abnormal spermatogonia morphology ( J:177420 )

♂ • some (about 5%) seminiferous tubules lack spermatogonia

decreased male germ cell number ( J:177420 )

♂ • progressive germ cell depletion

oligozoospermia ( J:177420 )

♂ • a 67% decrease in epididymal sperm concentration at 12 weeks of age

♂ • despite the decrease in sperm concentration, males are fertile

mortality/aging

mortality/aging ( J:177420 )

N • viable

liver/biliary system

increased hepatocellular carcinoma incidence ( J:177420 )

• increased incidence in males at 1 year of age and all affected mice have multiple hepatocellular carcinomas

reproductive system

abnormal spermatogonia morphology ( J:177420 )

♂ • some (about 5%) seminiferous tubules lack spermatogonia

decreased male germ cell number ( J:177420 )

♂ • progressive germ cell depletion

oligozoospermia ( J:177420 )

♂ • a 67% decrease in epididymal sperm concentration at 12 weeks of age

♂ • despite the decrease in sperm concentration, males are fertile

abnormal seminiferous tubule morphology ( J:177420 )

♂ • some tubules show progressive germ cell depletion, lack spermatogonia or contain a cohort of spermatocytes arrested in meiosis

small testis ( J:177420 )

♂ • detected at puberty and the difference in size compared to controls increases over time

increased ovary tumor incidence ( J:177420 )

♀ • at 1 year of age

arrest of male meiosis ( J:177420 )

♂ • about 5% of seminiferous tubules contain a cohort of spermatocytes arrested in meiosis

neoplasm

increased tumor incidence ( J:177420 )

• all males develop tumors by 1 year of age

increased ovary tumor incidence ( J:177420 )

♀ • at 1 year of age

increased hepatocellular carcinoma incidence ( J:177420 )

• increased incidence in males at 1 year of age and all affected mice have multiple hepatocellular carcinomas

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:177420 )

♂ • some tubules show progressive germ cell depletion, lack spermatogonia or contain a cohort of spermatocytes arrested in meiosis

small testis ( J:177420 )

♂ • detected at puberty and the difference in size compared to controls increases over time

increased ovary tumor incidence ( J:177420 )

♀ • at 1 year of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:177420