Phenotypes associated with this allele

• Allele Symbol: Tg(Snap25)40Micw
• Allele Name: transgene insertion 40, Michael C Wilson
• Allele ID: MGI:3851792
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cm/+ Tg(Snap25)40Micw/Tg(Snap25)40Micw	involves: C3H/HeJ * C57BL/6J	MGI:3851793
cx2	Cm/+ Tg(Snap25)40Micw/0	involves: C3H/HeJ * C57BL/6J	MGI:3851797

Genotype
MGI:3851793

cx1

• Allelic Composition: Cm/+; Tg(Snap25)40Micw/Tg(Snap25)40Micw
• Genetic Background: involves: C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:32588 , J:58598 )

N • the hyperactivity and suppressive effect of amphetamines found in the Cm/+ mice is rescued by homozygous expression of this transgene (J:32588)

N • tail-pinched induced theta wave in halothane anesthetized mice is normal, unlike that of Cm/+ mice without the transgene (J:58598)

N • paired pulse inhibition is normal and amphetamine treatment does not increase paired-pulse inhibition as it does in Cm/+ mice without the transgene (J:58598)

head bobbing ( J:32588 )

• despite homozygous expression of this transgene, these mice still display the head bobbing phenotype of Cm/+

vision/eye

abnormal eye development ( J:32588 )

• sunken, closed eyes characteristic of Cm/+ mice are still found despite the homozygous presence of this transgene

coloboma ( J:32588 )

Genotype
MGI:3851797

cx2

• Allelic Composition: Cm/+; Tg(Snap25)40Micw/0
• Genetic Background: involves: C3H/HeJ * C57BL/6J

behavior/neurological

hyperactivity ( J:32588 )

• while these mice display hyperactivity, it is decreased relative to Cm/+ mice without the transgene