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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6-Mef2c)2Jmol
transgene insertion 2, Jeffery D Molkentin
MGI:3851582
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Myh6-Mef2c)2Jmol/0
Tg(Myh6-Ppp3ca)37Eno/0
involves: FVB MGI:3851788
tg2
Tg(Myh6-Mef2c)2Jmol/0 involves: FVB MGI:3851787


Genotype
MGI:3851788
cx1
Allelic
Composition
Tg(Myh6-Mef2c)2Jmol/0
Tg(Myh6-Ppp3ca)37Eno/0
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-Mef2c)2Jmol mutation (1 available)
Tg(Myh6-Ppp3ca)37Eno mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• cardiac hypertrophy is not enhanced above that observed in Tg(Myh6-Mef2c)2Jmol single transgenic animals

cardiovascular system
• mice show large atrial clots
• cardiac hypertrophy is not enhanced above that observed in Tg(Myh6-Mef2c)2Jmol single transgenic animals
• degree of functional decompensation is not enhanced compared to Tg(Myh6-Mef2c)2Jmol single transgenic mice

muscle
• degree of functional decompensation is not enhanced compared to Tg(Myh6-Mef2c)2Jmol single transgenic mice




Genotype
MGI:3851787
tg2
Allelic
Composition
Tg(Myh6-Mef2c)2Jmol/0
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-Mef2c)2Jmol mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

cardiovascular system
• mice show large atrial clots
• mice show progressive ventricular chamber dilation
• ventricle weight (normalized to body weight) increases following the decrease in fractional shortening and ventricle dilation
• when subjected to transverse aortic constriction, mice die after 1-3 days due to pressure overload stimulation
• mice show a progressive decrease in fractional shortening

muscle
• when subjected to transverse aortic constriction, mice die after 1-3 days due to pressure overload stimulation
• mice show a progressive decrease in fractional shortening





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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory