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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(tetO-Dusp6)1Jmol
transgene insertion 1, Jeffery D Molkentin
MGI:3851561
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Myh6-tTA)55Rbns/0
Tg(tetO-Dusp6)1Jmol/0
involves: FVB/N MGI:3851933


Genotype
MGI:3851933
cx1
Allelic
Composition
Tg(Myh6-tTA)55Rbns/0
Tg(tetO-Dusp6)1Jmol/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-tTA)55Rbns mutation (1 available)
Tg(tetO-Dusp6)1Jmol mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• induced (removal of doxycycline treatment) mice show the same hypertrophic response to procedures such as transverse aortic constriction (TAC) and forced exercise as wild-type and single transgenic controls
• hypertrophy in response to agonists such as angiotensin II and isoproterenol is identical to that seen in treated wild-type after 14 days

cardiovascular system
• similar increase in myocyte cross-sectional area in left ventricle is observed in induced transgenic mice and controls after angiotensin II and isoproterenol infusion
• induced (removal of doxycycline treatment) mice show the same hypertrophic response to procedures such as transverse aortic constriction (TAC) and forced exercise as wild-type and single transgenic controls
• hypertrophy in response to agonists such as angiotensin II and isoproterenol is identical to that seen in treated wild-type after 14 days
• after 14 days of isoproterenol infusion, mice display 2-fold greater fibrosis than control mice
• medium- and high-expressing transgenic mice show significantly greater decompensation after 14 weeks of transverse aortic constriction compared to wild-type
• 1 week of acute pressure overload caused increased TUNEL rates in high- and medium-expressing mice and remain elevated after 14 weeks of TAC in high-expressing mice

muscle
• similar increase in myocyte cross-sectional area in left ventricle is observed in induced transgenic mice and controls after angiotensin II and isoproterenol infusion
• medium- and high-expressing transgenic mice show significantly greater decompensation after 14 weeks of transverse aortic constriction compared to wild-type
• 1 week of acute pressure overload caused increased TUNEL rates in high- and medium-expressing mice and remain elevated after 14 weeks of TAC in high-expressing mice

respiratory system

cellular
• 1 week of acute pressure overload caused increased TUNEL rates in high- and medium-expressing mice and remain elevated after 14 weeks of TAC in high-expressing mice





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory