Phenotypes associated with this allele

• Allele Symbol: Tg(Mt1-CBS)25Waku
• Allele Name: transgene insertion 25, Warren Kruger
• Allele ID: MGI:3851387
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cbs^tm1Unc/Cbs^tm1Unc Tg(Mt1-CBS)25Waku/0	involves: 129P2/OlaHsd * C3H * C57BL/6	MGI:3851397
cx2	Apoe^tm1Unc/Apoe^tm1Unc Cbs^tm1Unc/Cbs^tm1Unc Tg(Mt1-CBS)25Waku/0	involves: 129P2/OlaHsd * C3H * C57BL/6	MGI:5796685

Genotype
MGI:3851397

cx1

• Allelic Composition: Cbs^tm1Unc/Cbs^tm1Unc; Tg(Mt1-CBS)25Waku/0
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal amino acid level ( J:150548 )

• liver N-homocysteine levels in zinc-induced mice are 3.4-fold higher than in Cbs^tm1Unc Tg(Mt1-CBS)25Waku heterozygotes

• N-homocysteine levels are 3.3-fold lower than in Cbs^tm1Unc/Cbs^tm1Unc Tg(MT1-CBS*I278T)1Waku mice

abnormal circulating homocysteine level ( J:150548 )

• plasma N-homocysteine levels in zinc-induced mice are 4.2-fold higher than Cbs^tm1Unc Tg(Mt1-CBS)25Waku heterozygotes

Genotype
MGI:5796685

cx2

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Cbs^tm1Unc/Cbs^tm1Unc; Tg(Mt1-CBS)25Waku/0
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

cardiovascular system

increased susceptibility to atherosclerosis ( J:168131 )

• zinc-induced mice fed a high-fat diet exhibit increased atherosclerotic lesions compared to controls

• zinc-induced mice fed a high-fat diet exhibit enhanced Ly-6C monocyte/macrophage accumulation in atherosclerotic lesions

growth/size/body

decreased body weight ( J:168131 )

• zinc-induced mice fed a high fat diet develop severe hyperhomocysteinemia associated with a 15.6% reduction in body weight

hematopoietic system

increased monocyte cell number ( J:168131 )

• increase in monocyte population in blood, spleen, and bone marrow of 15 months old zinc-induced mice fed a regular diet

increased Ly6C high monocyte number ( J:168131 )

• zinc-induced mice fed a regular diet with severe hyperhomocysteinemia exhibit elevated CD11b+Ly-6C^hi and CD11b+Ly-6C^mid inflammatory monocyte subsets

homeostasis/metabolism

increased circulating homocysteine level ( J:168131 )

• plasma homocysteine levels are increased in zinc-induced mutants fed a regular or a high-fat diet

increased circulating methionine level ( J:168131 )

• plasma methionine levels are increased in zinc-induced mutants fed a regular diet

• however, methionine levels are normal in zinc-induced mutants fed a high-fat diet

increased circulating tumor necrosis factor level ( J:168131 )

• high-fat diet fed zinc-induced mice show increased plasma levels of the proinflammatory cytokine TNF-alpha and the chemotactic factor MCP-1

immune system

increased monocyte cell number ( J:168131 )

• increase in monocyte population in blood, spleen, and bone marrow of 15 months old zinc-induced mice fed a regular diet

increased Ly6C high monocyte number ( J:168131 )

• zinc-induced mice fed a regular diet with severe hyperhomocysteinemia exhibit elevated CD11b+Ly-6C^hi and CD11b+Ly-6C^mid inflammatory monocyte subsets

increased circulating tumor necrosis factor level ( J:168131 )

• high-fat diet fed zinc-induced mice show increased plasma levels of the proinflammatory cytokine TNF-alpha and the chemotactic factor MCP-1

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
homocystinuria		DOID:9263	OMIM:236200 OMIM:236250	J:168131