Phenotypes associated with this allele

• Allele Symbol: Slc46a1^tm1Hija
• Allele Name: targeted mutation 1, Hieronim Jakubowski
• Allele ID: MGI:3851364
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc46a1^tm1Hija/Slc46a1^tm1Hija	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3851390

Genotype
MGI:3851390

hm1

• Allelic Composition: Slc46a1^tm1Hija/Slc46a1^tm1Hija
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal amino acid level ( J:150548 )

• liver N-homocysteine and total homocysteine levels are increased 3.6- and 5.1-fold, respectively, compared to in wild-type mice

increased circulating homocysteine level ( J:150548 )

• plasma N-homocysteine levels are 30-fold higher than in heterozygous and wild-type mice

• total plasma homocysteine levels are 65-fold higher than in heterozygous and wild-type mice