About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Scn1a*)RH9Aesc
transgene insertion RH9, Andrew Escayg
MGI:3851210
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Scn1atm1Wac/Scn1atm1Wac
Tg(Scn1a*)RH9Aesc/0
involves: 129S1/Sv * 129X1/SvJ * FVB/NJ MGI:3851213
cx2
Scn1atm1Wac/Scn1a+
Tg(Scn1a*)RH9Aesc/0
involves: 129S1/Sv * 129X1/SvJ * FVB/NJ MGI:3851214
tg3
Tg(Scn1a*)RH9Aesc/0 involves: FVB/NJ MGI:3851211


Genotype
MGI:3851213
cx1
Allelic
Composition
Scn1atm1Wac/Scn1atm1Wac
Tg(Scn1a*)RH9Aesc/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn1atm1Wac mutation (0 available); any Scn1a mutation (75 available)
Tg(Scn1a*)RH9Aesc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• a few mice survive beyond weaning but mice rarely survive past 6 months of age
• unlike homozygous mice not carrying the transgene which all die by P15, most mice carrying the transgene die between P17 and P21




Genotype
MGI:3851214
cx2
Allelic
Composition
Scn1atm1Wac/Scn1a+
Tg(Scn1a*)RH9Aesc/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn1atm1Wac mutation (0 available); any Scn1a mutation (75 available)
Tg(Scn1a*)RH9Aesc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• substantial improvement in life span compared to heterozygous mice not carrying the transgene; 50% survival at 6 months of age compared to 25%




Genotype
MGI:3851211
tg3
Allelic
Composition
Tg(Scn1a*)RH9Aesc/0
Genetic
Background
involves: FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• decreased threshold for kainic acid induced seizures compared to control transgenic lines
• the ratio of sodium current densities in bipolar versus pyramidal neurons is reduced and the sodium current density in bipolar cells is reduced compared to controls
• sodium channels appear to recover more slowly from inactivation and current through the channels decreases during a series of depolarizations in bipolar neurons
• in pyramidal neurons a negative shift is seen in the voltage dependence of inactivation

behavior/neurological
• decreased threshold for kainic acid induced seizures compared to control transgenic lines

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
generalized epilepsy with febrile seizures plus DOID:0060170 J:150454





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/28/2022
MGI 6.20
The Jackson Laboratory