Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn1atm1Wac mutation
(0 available);
any
Scn1a mutation
(114 available)
Tg(Scn1a*)RH9Aesc mutation
(0 available)
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mortality/aging
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• a few mice survive beyond weaning but mice rarely survive past 6 months of age
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• unlike homozygous mice not carrying the transgene which all die by P15, most mice carrying the transgene die between P17 and P21
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn1atm1Wac mutation
(0 available);
any
Scn1a mutation
(114 available)
Tg(Scn1a*)RH9Aesc mutation
(0 available)
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mortality/aging
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• substantial improvement in life span compared to heterozygous mice not carrying the transgene; 50% survival at 6 months of age compared to 25%
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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nervous system
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• decreased threshold for kainic acid induced seizures compared to control transgenic lines
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• the ratio of sodium current densities in bipolar versus pyramidal neurons is reduced and the sodium current density in bipolar cells is reduced compared to controls
• sodium channels appear to recover more slowly from inactivation and current through the channels decreases during a series of depolarizations in bipolar neurons
• in pyramidal neurons a negative shift is seen in the voltage dependence of inactivation
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behavior/neurological
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• decreased threshold for kainic acid induced seizures compared to control transgenic lines
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Analysis Tools