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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Cd8a-cre)1Itan
transgene insertion 1, Ichiro Taniuchi
MGI:3851193
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Zbtb7btm6.1Itan/Zbtb7btm6.1Itan
Tg(Cd8a-cre)1Itan/?
involves: C57BL/6 MGI:5506931
cn2
Pik3c3tm1.1Flv/Pik3c3tm1.1Flv
Tg(Cd8a-cre)1Itan/0
involves: C57BL/6 * C57BL/6N MGI:5427890
cn3
Notch2tm1.1Hhi/Notch2tm1.1Hhi
Tg(Cd8a-cre)1Itan/0
involves: C57BL/6 * CBA MGI:3851205


Genotype
MGI:5506931
cn1
Allelic
Composition
Zbtb7btm6.1Itan/Zbtb7btm6.1Itan
Tg(Cd8a-cre)1Itan/?
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd8a-cre)1Itan mutation (1 available)
Zbtb7btm6.1Itan mutation (0 available); any Zbtb7b mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• CD8+ T cell development is normal




Genotype
MGI:5427890
cn2
Allelic
Composition
Pik3c3tm1.1Flv/Pik3c3tm1.1Flv
Tg(Cd8a-cre)1Itan/0
Genetic
Background
involves: C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3c3tm1.1Flv mutation (0 available); any Pik3c3 mutation (35 available)
Tg(Cd8a-cre)1Itan mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• T cell development is normal
• CD8+ T cells exhibit increased spontaneous apoptosis ex vivo compared with wild-type cells
• T cell lymphopenia is cell autonomous based on bone marrow chimera experiments
• CD4+ T cells exhibit increased mitochondrial mass compared with control cells
• CD4+ and CD8+ T cells exhibit increased reactive oxygen species compared with control cells
• CD8+ T cells exhibit increased mitochondrial mass compared with control cells
• CD4+ and CD8+ T cells exhibit increased reactive oxygen species compared with control cells

cellular
• CD8+ and to a lesser extent CD4+ T cells exhibit increased mitochondrial mass compared with control cells
• CD8+ T cells exhibit increased spontaneous apoptosis ex vivo compared with wild-type cells
• mitophagy is reduced in CD8+ and CD4+ T cells
• CD4+ and CD8+ T cells exhibit increased reactive oxygen species compared with control cells

hematopoietic system
• CD8+ T cells exhibit increased spontaneous apoptosis ex vivo compared with wild-type cells
• T cell lymphopenia is cell autonomous based on bone marrow chimera experiments
• CD4+ T cells exhibit increased mitochondrial mass compared with control cells
• CD4+ and CD8+ T cells exhibit increased reactive oxygen species compared with control cells
• CD8+ T cells exhibit increased mitochondrial mass compared with control cells
• CD4+ and CD8+ T cells exhibit increased reactive oxygen species compared with control cells




Genotype
MGI:3851205
cn3
Allelic
Composition
Notch2tm1.1Hhi/Notch2tm1.1Hhi
Tg(Cd8a-cre)1Itan/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2tm1.1Hhi mutation (1 available); any Notch2 mutation (67 available)
Tg(Cd8a-cre)1Itan mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• cells produce less granzyme B than control cells after stimulation with allogeneic control dendritic cells (DCs) or DL1-DCs
• mice, injected with spleen cells that were pulsed with OT-I (ova) peptide and 4 days later given labeled spleen cells or labeled spleen cells that were pulsed with OT-I (ova) peptide show little CTL-mediated killing of either population; in contrast, control mice display preferential cytolysis of OT-I pulsed spleen cells
• mice display much earlier death after Trypanosoma cruzi infection compared to controls

hematopoietic system
• cells produce less granzyme B than control cells after stimulation with allogeneic control dendritic cells (DCs) or DL1-DCs
• mice, injected with spleen cells that were pulsed with OT-I (ova) peptide and 4 days later given labeled spleen cells or labeled spleen cells that were pulsed with OT-I (ova) peptide show little CTL-mediated killing of either population; in contrast, control mice display preferential cytolysis of OT-I pulsed spleen cells





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory