Phenotypes associated with this allele

• Allele Symbol: Igh^{tm1.1(Tag)Rwhe}
• Allele Name: targeted mutation 1.1, Rudolf Hendriks
• Allele ID: MGI:3850722
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Igh^tm1.1(Tag)Rwhe/Igh^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3850821
cx2	Igh^tm1.1(Tag)Rwhe/Igh^+ Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:3850824

Genotype
MGI:3850821

ht1

• Allelic Composition: Igh^{tm1.1(Tag)Rwhe}/Igh⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased leukemia incidence ( J:150315 )

• the expansion of a monoclonal B cell population in a small percentage of mice is indicative of leukemia

increased chronic lymphocytic leukemia incidence ( J:150315 )

immune system

enlarged spleen ( J:150315 )

• spleen size is increased with age in a small percentage of mice

abnormal B cell morphology ( J:150315 )

• a small percentage of mice have a large population of monoclonal B cells that emerges with age

• these monoclonal B cells are larger in size and number, and have clumped chromatin with little cytoplasm

increased B cell number ( J:150315 )

• a small percentage of mice have increased B cells in the blood due to the emergence of a monoclonal population

lymph node hyperplasia ( J:150315 )

• about 60% of mice with a monoclonal B cell population display lymph node hyperplasia with numbers being up to 15 fold higher than controls

hematopoietic system

enlarged spleen ( J:150315 )

• spleen size is increased with age in a small percentage of mice

abnormal B cell morphology ( J:150315 )

• a small percentage of mice have a large population of monoclonal B cells that emerges with age

• these monoclonal B cells are larger in size and number, and have clumped chromatin with little cytoplasm

increased B cell number ( J:150315 )

• a small percentage of mice have increased B cells in the blood due to the emergence of a monoclonal population

growth/size/body

enlarged spleen ( J:150315 )

• spleen size is increased with age in a small percentage of mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:150315

Genotype
MGI:3850824

cx2

• Allelic Composition: Igh^{tm1.1(Tag)Rwhe}/Igh⁺; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

neoplasm

increased leukemia incidence ( J:150315 )

• 4 of 10 mice develop B cell leukemia compared to Trp53 null controls that develop T cell lymphomas

• median tumor-free survival is 143 days compared to over 365 days in transgenic controls on a wild-type Trp53 background

increased chronic lymphocytic leukemia incidence ( J:150315 )