All Phenotypes Nlrp3<tm2Hhf> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nlrp3^tm2Hhf
targeted mutation 2, Hal M Hoffman
MGI:3850013

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nlrp3^tm2Hhf/Nlrp3⁺ Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:3850048
cn2	Nlrp3^tm2Hhf/Nlrp3⁺ Tg(CAG-cre/Esr1*)5Amc/?	involves: 129/Sv * C57BL/6 * CBA	MGI:3850052
cx3	Nlrp3^tm2Hhf/Nlrp3^tm2Hhf Vsig4^tm1Gne/Vsig4^tm1Gne	B6.Cg-Nlrp3^tm2Hhf Vsig4^tm1Gne	MGI:6384868
cx4	Nlrp3^tm2Hhf/Nlrp3⁺ Tg(CAG-cre/Esr1*)5Amc/?	involves: 129/Sv * C57BL/6 * CBA	MGI:3850051

Allelic Composition	Nlrp3^tm2Hhf/Nlrp3⁺ Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Nlrp3^tm2Hhf mutation (1 available); any Nlrp3 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:150054 )

• mice are either stillborn or day within one day of birth

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial cold autoinflammatory syndrome 1		DOID:0090062	OMIM:120100	J:150054

Allelic Composition	Nlrp3^tm2Hhf/Nlrp3⁺ Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background	involves: 129/Sv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3^tm2Hhf mutation (1 available); any Nlrp3 mutation (61 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal macrophage physiology ( J:150054 )

• peritoneal macrophages are able to secrete IL-1beta in the absence of ATP when activated in vitro

abnormal dendritic cell physiology ( J:150054 )

• bone marrow derived dendritic cells (DCs) spontaneously secrete high levels of IL1-beta in response to cold (32 degrees) incubation

• DCs also hypersecrete the mature form of IL-1beta in response to activation

• the maximal response is 150-fold greater than controls

• DCs are able to secrete IL1-beta without the presence of exogenous ATP

hematopoietic system

abnormal macrophage physiology ( J:150054 )

• peritoneal macrophages are able to secrete IL-1beta in the absence of ATP when activated in vitro

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial cold autoinflammatory syndrome 1		DOID:0090062	OMIM:120100	J:150054

Allelic Composition	Nlrp3^tm2Hhf/Nlrp3^tm2Hhf Vsig4^tm1Gne/Vsig4^tm1Gne
Genetic Background	B6.Cg-Nlrp3^tm2Hhf Vsig4^tm1Gne

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3^tm2Hhf mutation (1 available); any Nlrp3 mutation (61 available)
Vsig4^tm1Gne mutation (0 available); any Vsig4 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:281762 )

• MOG35-55 treated mice exhibit reduced clinical score compared with Vsig4^tm1Gne homozygotes

Allelic Composition	Nlrp3^tm2Hhf/Nlrp3⁺ Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background	involves: 129/Sv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3^tm2Hhf mutation (1 available); any Nlrp3 mutation (61 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

slow postnatal weight gain ( J:150054 )

• some older mice have slower weight gain

immune system

skin inflammation ( J:150054 )

• some older mice develop skin inflammation suggesting leaky expression of the cre recombinase

integument

skin inflammation ( J:150054 )

• some older mice develop skin inflammation suggesting leaky expression of the cre recombinase

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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