Mouse Genome Informatics
hm1
    Glis3tm1Hiha/Glis3tm1Hiha
involves: C57BL/6 * CBA
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die within 5 days of birth
• survival may be extended up to P9 when separated from wild-type and heterozygous littermates

homeostasis/metabolism
• glucose intolerant

renal/urinary system
• at P7, tiny cysts can be seen in the nephrogenic zone of the cortex
• at P0, large cysts are seen in the intermediate area between the cortex and pelvis
• some cysts originate from Bowman's capsules
• at P7, cysts in the intermediate are increased in size and tiny cysts can be seen in the nephrogenic zone of the cortex

endocrine/exocrine glands
• histology suggests hypothyroidism
• RT-PCR analysis indicates reduced expression of pancreatic hormones

growth/size/body
• display severe ateliosis despite presence of milk in the stomach