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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Glis3tm1Hiha
targeted mutation 1, Hisashi Hashimoto
MGI:3849863
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Glis3tm1Hiha/Glis3tm1Hiha involves: C57BL/6 * CBA MGI:3849867


Genotype
MGI:3849867
hm1
Allelic
Composition
Glis3tm1Hiha/Glis3tm1Hiha
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glis3tm1Hiha mutation (1 available); any Glis3 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die within 5 days of birth
• survival may be extended up to P9 when separated from wild-type and heterozygous littermates

homeostasis/metabolism
• glucose intolerant

renal/urinary system
• at P7, tiny cysts can be seen in the nephrogenic zone of the cortex
• at P0, large cysts are seen in the intermediate area between the cortex and pelvis
• some cysts originate from Bowman's capsules
• at P7, cysts in the intermediate are increased in size and tiny cysts can be seen in the nephrogenic zone of the cortex

endocrine/exocrine glands
• histology suggests hypothyroidism
• RT-PCR analysis indicates reduced expression of pancreatic hormones

growth/size/body
• display severe ateliosis despite presence of milk in the stomach





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory