Phenotypes associated with this allele

• Allele Symbol: Klf5^tm1Yfk
• Allele Name: targeted mutation 1, Yoshiaki Fujii-Kuriyama
• Allele ID: MGI:3849301
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klf5^tm1Yfk/Klf5^tm1Yfk	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)	MGI:3849309

Genotype
MGI:3849309

hm1

• Allelic Composition: Klf5^tm1Yfk/Klf5^tm1Yfk
• Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality at implantation, complete penetrance ( J:149868 )

• embryos fail to implant due to defective trophectoderm development

• blastocytes are found at the expected Mendelian frequency

embryo

abnormal inner cell mass morphology ( J:149868 )

• embryonic stem cells cannot be isolated from the inner cell mass of blastocytes

abnormal trophectoderm morphology ( J:149868 )

• embryos have abnormal development of the trophoectoderm that leads to a failure to implant

reproductive system

failure of embryo implantation ( J:149868 )

• mutant embryos fail to implant

• tetraploid complementation (where wild-type cells contribute to the trophectoderm while mutant ES cells form the inner cell mass) leads to successful implantation