All Phenotypes Fmn1<tm2Made> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fmn1^tm2Made
targeted mutation 2, Markus Dettenhofer
MGI:3848983

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fmn1^tm2Made/Fmn1^tm2Made	involves: 129S6/SvEvTac * C57BL/6J	MGI:3848988
hm2	Fmn1^tm2Made/Fmn1^tm2Made	involves: 129S6/SvEvTac * C57BL/6J * FVB/N	MGI:3848989
cx3	Fmn1^tm2Made/Fmn1⁺ Grem1^tm1Azun/Grem1⁺	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J	MGI:3848990

Allelic Composition	Fmn1^tm2Made/Fmn1^tm2Made
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmn1^tm2Made mutation (1 available); any Fmn1 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal autopod morphology ( J:149484 )

• autopods exhibit a loss of a digit and soft tissue fusion of the middle digits unlike in wild-type mice

• hindlimb autopods exhibit a metatarsal fusion of the two posterior digits unlike in wild-type mice

oligodactyly ( J:149484 )

• 66% of mice exhibit reduced digit number to four in both the forelimb and hindlimb

absent fibula ( J:149484 )

fused metatarsal bones ( J:149484 )

• in the hindlimb

renal/urinary system

single kidney ( J:149484 )

• 4.4% of mice exhibit unilateral renal aplasia unlike in wild-type mice

skeleton

absent fibula ( J:149484 )

fused metatarsal bones ( J:149484 )

• in the hindlimb

Allelic Composition	Fmn1^tm2Made/Fmn1^tm2Made
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmn1^tm2Made mutation (1 available); any Fmn1 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal autopod morphology ( J:149484 )

• autopods exhibit a loss of a digit and soft tissue fusion of the middle digits unlike in wild-type mice

• hindlimb autopods exhibit a metatarsal fusion of the two posterior digits unlike in wild-type mice

oligodactyly ( J:149484 )

• 100% of mice exhibit reduced digit number to four in both the forelimb and hindlimb

absent fibula ( J:149484 )

fused metatarsal bones ( J:149484 )

• in the hindlimb

renal/urinary system

single kidney ( J:149484 )

• 50% of mice exhibit unilateral renal aplasia unlike in wild-type mice

skeleton

absent fibula ( J:149484 )

fused metatarsal bones ( J:149484 )

• in the hindlimb

Allelic Composition	Fmn1^tm2Made/Fmn1⁺ Grem1^tm1Azun/Grem1⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmn1^tm2Made mutation (1 available); any Fmn1 mutation (75 available)
Grem1^tm1Azun mutation (1 available); any Grem1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal limb development ( J:149484 )

• authors state that mice exhibit similar limb defects as those observed in Fmn1^tm2Made homozygotes

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