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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Cdh5-cre/ERT2)1Rha
transgene insertion 1, Ralf H Adams
MGI:3848982
Summary 32 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gpr182tm2c(KOMP)Wtsi/Gpr182tm2c(KOMP)Wtsi
Tg(Cdh5-cre/ERT2)1Rha/0
B6.Cg-Gpr182tm2c(KOMP)Wtsi Tg(Cdh5-cre/ERT2)1Rha MGI:6712273
cn2
Dll1tm1Mjo/Dll1tm1Mjo
Tg(Cdh5-cre/ERT2)1Rha/0
involves: 129 MGI:3848985
cn3
Ccm2tm1Mlkn/Ccm2tm1Mlkn
Tg(Cdh5-cre/ERT2)1Rha/0
involves: 129 MGI:6279212
cn4
Ccm2tm1.1Etl/Ccm2tm1Etl
Tg(Cdh5-cre/ERT2)1Rha/0
involves: 129 * C57BL/6 MGI:5297594
cn5
Ccm2tm1Mlkn/Ccm2tm1Mlkn
Map3k3tm1.1Mlkn/Map3k3+
Tg(Cdh5-cre/ERT2)1Rha/0
involves: 129 * C57BL/6NTac MGI:6279213
cn6
Nus1tm1.1Qrm/Nus1tm1.1Qrm
Tg(Cdh5-cre/ERT2)1Rha/0
involves: 129P2/OlaHsd * C57BL/6 MGI:6361030
cn7
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Pfkfb3tm1Pec/Pfkfb3tm1Pec
Tg(Cdh5-cre/ERT2)1Rha/0
involves: 129S1/Sv * 129X1/SvJ MGI:5825525
cn8
Sox17tm2Sjm/Sox17tm2Sjm
Tg(Cdh5-cre/ERT2)1Rha/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5792803
cn9
Gipc1tm1.1Mhsi/Gipc1tm1.1Mhsi
Tg(Cdh5-cre/ERT2)1Rha/?
involves: 129S1/SvImJ * 129S4/SvJaeSor * C57BL/6 MGI:5696330
cn10
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
S1pr1tm2Rlp/S1pr1tm2Rlp
Tg(Cdh5-cre/ERT2)1Rha/0
involves: 129S6/SvEvTac * 129X1/SvJ MGI:5445987
cn11
Klf2tm1Mlkn/Klf2tm1Mlkn
Krit1tm1Kwhi/Krit1tm1Kwhi
Tg(Cdh5-cre/ERT2)1Rha/0
involves: 129S6/SvEvTac * C57BL/6NCrl MGI:6279217
cn12
Klf4tm1Khk/Klf4+
Krit1tm1Kwhi/Krit1tm1Kwhi
Tg(Cdh5-cre/ERT2)1Rha/0
involves: 129S6/SvEvTac * C57BL/6NCrl MGI:6279218
cn13
Krit1tm1Kwhi/Krit1tm1Kwhi
Tg(Cdh5-cre/ERT2)1Rha/0
involves: 129S6/SvEvTac * C57BL/6NCrl MGI:6279211
cn14
Klf2tm1Mlkn/Klf2+
Krit1tm1Kwhi/Krit1tm1Kwhi
Tg(Cdh5-cre/ERT2)1Rha/0
involves: 129S6/SvEvTac * C57BL/6NCrl MGI:6279216
cn15
Krit1tm1Kwhi/Krit1tm1Kwhi
Map3k3tm1.1Mlkn/Map3k3+
Tg(Cdh5-cre/ERT2)1Rha/0
involves: 129S6/SvEvTac * C57BL/6NCrl * C57BL/6NTac MGI:6279215
cn16
Nus1tm1Wcsa/Nus1+
Rtn4tm1Matl/Rtn4tm1Matl
Tg(Cdh5-cre/ERT2)1Rha/0
involves: 129S7/SvEvBrd MGI:6361104
cn17
Amotl1tm1Laho/Amotl1tm1Laho
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Tg(Cdh5-cre/ERT2)1Rha/0
involves: 129X1/SvJ * C57BL/6 MGI:6723729
cn18
Amotl2tm1.1Laho/Amotl2+
Tg(Cdh5-cre/ERT2)1Rha/0
involves: C57BL/6 MGI:6121066
cn19
Amotl2tm1.1Laho/Amotl2tm1.1Laho
Tg(Cdh5-cre/ERT2)1Rha/0
involves: C57BL/6 MGI:6121065
cn20
Pdcd10tm1Arte/Pdcd10tm1Arte
Tg(Cdh5-cre/ERT2)1Rha/0
involves: C57BL/6 MGI:5297596
cn21
Krit1tm1Arte/Krit1tm1Arte
Tg(Cdh5-cre/ERT2)1Rha/0
involves: C57BL/6 MGI:5297595
cn22
Lypla1tm1Sem/Lypla1tm1Sem
Tg(Cdh5-cre/ERT2)1Rha/0
involves: C57BL/6 MGI:6514412
cn23
Amotl1tm1Laho/Amotl1tm1Laho
Tg(Cdh5-cre/ERT2)1Rha/0
involves: C57BL/6 MGI:6723732
cn24
Rhojtm1.1Auem/Rhojtm1.1Auem
Tg(Cdh5-cre/ERT2)1Rha/0
involves: C57BL/6 * CBA/JNCrlj MGI:5608673
cn25
Amotl1tm1Laho/Amotl1tm1Laho
Tg(Cdh5-cre/ERT2)1Rha/0
Tg(MMTV-PyVT)634Mul/0
involves: C57BL/6 * FVB/N MGI:6723730
cn26
Flvcr2tm1.1Tda/Flvcr2tm1.2Tda
Tg(Cdh5-cre/ERT2)1Rha/0
involves: C57BL/6J MGI:6415692
cn27
Flvcr2tm1.1Tda/Flvcr2tm1.1Tda
Tg(Cdh5-cre/ERT2)1Rha/0
involves: C57BL/6J MGI:6415689
cn28
Sdc2tm1c(KOMP)Wtsi/Sdc2tm1c(KOMP)Wtsi
Tg(Cdh5-cre/ERT2)1Rha/0
involves: C57BL/6J * C57BL/6N MGI:6364849
cn29
Pfn1tm1Foxp/Pfn1tm1Foxp
Tg(Cdh5-cre/ERT2)1Rha/0
involves: C57BL/6NTac MGI:5470092
cn30
Cdh5tm1Dvst/Cdh5tm1Dvst
Tg(Cdh5-cre/ERT2)1Rha/0
Not Specified MGI:5445989
cn31
Cpt1atm1.1Pec/Cpt1atm1.1Pec
Tg(Cdh5-cre/ERT2)1Rha/0
Not Specified MGI:5771679
cn32
Nus1tm1Wcsa/Nus1tm1Wcsa
Tg(Cdh5-cre/ERT2)1Rha/0
Not Specified MGI:6361095


Genotype
MGI:6712273
cn1
Allelic
Composition
Gpr182tm2c(KOMP)Wtsi/Gpr182tm2c(KOMP)Wtsi
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
B6.Cg-Gpr182tm2c(KOMP)Wtsi Tg(Cdh5-cre/ERT2)1Rha
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr182tm2c(KOMP)Wtsi mutation (0 available); any Gpr182 mutation (12 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mice show an increase in colony-forming units of hematopoietic stem/progenitors in the peripheral blood and in the spleen, paralleled by an increase in c-Kit+ cells in the spleen, following tamoxifen treatment
• mice show increased levels of neutrophils and monocytes in peripheral blood following induction with tamoxifen
• mice show increased levels of neutrophils and monocytes in peripheral blood following induction with tamoxifen
• mice show a decrease in long-term repopulating hematopoietic stem cells (LT-HSCs; CD150+CD48-CD34low LSK) in the bone marrow following induction with tamoxifen
• however, progenitor populations are not affected

homeostasis/metabolism
• mice induced with tamoxifen show a rapid increase in plasma concentration of CXCL10, CXCL12, and CXCL13, with increase of CXCL13 more pronounced than the other two
• levels of CXCL12 and CXCL10 remain stable over a period of 20 days while CXCL13 levels continue to increase after induction
• however, no alteration in the distribution of CXCL12 is seen in the bone marrow
• plasma concentration of CXCL10 is increased following tamoxifen treatment

immune system
• mice show increased levels of neutrophils and monocytes in peripheral blood following induction with tamoxifen
• mice show increased levels of neutrophils and monocytes in peripheral blood following induction with tamoxifen
• mice induced with tamoxifen show a rapid increase in plasma concentration of CXCL10, CXCL12, and CXCL13, with increase of CXCL13 more pronounced than the other two
• levels of CXCL12 and CXCL10 remain stable over a period of 20 days while CXCL13 levels continue to increase after induction
• however, no alteration in the distribution of CXCL12 is seen in the bone marrow
• plasma concentration of CXCL10 is increased following tamoxifen treatment




Genotype
MGI:3848985
cn2
Allelic
Composition
Dll1tm1Mjo/Dll1tm1Mjo
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation (2 available); any Dll1 mutation (34 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• significant increase in capillary branch points in the skin is observed at E17.5
• lumens of large arteries show a reduction in diameters after tamoxifen induction at E18.5, with no significant differences in arterial wall thickness
• lumen shows a reduction in diameter compared to controls




Genotype
MGI:6279212
cn3
Allelic
Composition
Ccm2tm1Mlkn/Ccm2tm1Mlkn
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2tm1Mlkn mutation (0 available); any Ccm2 mutation (42 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice injected with tamoxifen at P1 exhibit cerebral cavernous malformation lesions by P13

nervous system
• mice injected with tamoxifen at P1 exhibit cerebral cavernous malformation lesions by P13

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cerebral cavernous malformation 2 DOID:0060670 OMIM:603284
J:250906




Genotype
MGI:5297594
cn4
Allelic
Composition
Ccm2tm1.1Etl/Ccm2tm1Etl
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2tm1.1Etl mutation (0 available); any Ccm2 mutation (42 available)
Ccm2tm1Etl mutation (0 available); any Ccm2 mutation (42 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice injected with tamoxifen at P1 to induce recombination exhibit an median survival time of 17 days

cardiovascular system
• endothelial cell-cell junctions are altered in cerebellar vessels of mutants injected with tamoxifen at P1
• mice injected with tamoxifen at P1 do not exhibit increased endothelial cell proliferation at P6
• mice injected with tamoxifen at P1 develop cerebral cavernous malformation (CCM) lesions within the CNS beginning at P6
• CCM lesions that develop in mutants injected with tamoxifen affect the venous bed but not the arterial compartment
• mice injected with tamoxifen at 3 weeks of age do not exhibit any gross cerebrovascular phenotype, indicating that deletion of Ccm2 at three weeks of age does not lead to cerebral cavernous malformations
• fetuses at E19.5 of pregnant mice injected with tamoxifen at E14.5, exhibit vascular anomalies on the cerebral hemispheres with irregular and tortuous rhinal cerebral veins surrounded by abnormal capillaries
• mice injected with tamoxifen at P4 show a milder phenotype compared to tamoxifen treatment at P1, with single isolated caverns located within the cerebellum without sign of hemorrhage
• mice injected with tamoxifen at P1 show CCM vascular malformations at the periphery of the retinal vascular plexus in both eyes
• CCM malformations at the periphery of the retinas are restricted to veins and the surrounding capillaries
• mice injected with tamoxifen at P1 show a thicker vascular plexus at the venous leading edge of the retina at P7, with a 29% increase in vascular coverage compared to controls and dilated main veins by P9, with abnormal capillaries at the periphery of the vascular plexus
• by 3 weeks of age, mice injected with tamoxifen at P1 do not exhibit three distinguished vascular plexuses in the retinas as seen in controls, and the vasculature from the lesion is composed by bubble like vascular structures packed together
• cerebellar lesions of tamoxifen treated mice are composed of dilated vessels full of blood cells, and in severe cases there are signs of hemorrhage
• mice injected with tamoxifen at P1 exhibit dilation of vessels from the pial surface of the cerebellum and dilation of vessels running along the cerebellar folia at the meningeal surface corresponding to dorsal cerebellar veins
• extensive cerebral hemorrhages are seen mostly around the multiple caverns composing cerebral cavernous malformation lesions in mice before death
• fetuses at E19.5 of pregnant mice injected with tamoxifen at E14.5, exhibit hemorrhagic skin

nervous system
• mice injected with tamoxifen at P1 develop cerebral cavernous malformation (CCM) lesions within the CNS beginning at P6
• CCM lesions that develop in mutants injected with tamoxifen affect the venous bed but not the arterial compartment
• mice injected with tamoxifen at 3 weeks of age do not exhibit any gross cerebrovascular phenotype, indicating that deletion of Ccm2 at three weeks of age does not lead to cerebral cavernous malformations
• fetuses at E19.5 of pregnant mice injected with tamoxifen at E14.5, exhibit vascular anomalies on the cerebral hemispheres with irregular and tortuous rhinal cerebral veins surrounded by abnormal capillaries
• mice injected with tamoxifen at P4 show a milder phenotype compared to tamoxifen treatment at P1, with single isolated caverns located within the cerebellum without sign of hemorrhage
• extensive cerebral hemorrhages are seen mostly around the multiple caverns composing cerebral cavernous malformation lesions in mice before death
• mice injected with tamoxifen at P1 develop cerebral cavernous malformation lesions within the cerebellum beginning at P6

vision/eye
• mice injected with tamoxifen at P1 show CCM vascular malformations at the periphery of the retinal vascular plexus in both eyes
• CCM malformations at the periphery of the retinas are restricted to veins and the surrounding capillaries
• mice injected with tamoxifen at P1 show a thicker vascular plexus at the venous leading edge of the retina at P7, with a 29% increase in vascular coverage compared to controls and dilated main veins by P9, with abnormal capillaries at the periphery of the vascular plexus
• by 3 weeks of age, mice injected with tamoxifen at P1 do not exhibit three distinguished vascular plexuses in the retinas as seen in controls, and the vasculature from the lesion is composed by bubble like vascular structures packed together

integument
• fetuses at E19.5 of pregnant mice injected with tamoxifen at E14.5, exhibit hemorrhagic skin

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cerebral cavernous malformation 2 DOID:0060670 OMIM:603284
J:177584




Genotype
MGI:6279213
cn5
Allelic
Composition
Ccm2tm1Mlkn/Ccm2tm1Mlkn
Map3k3tm1.1Mlkn/Map3k3+
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: 129 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2tm1Mlkn mutation (0 available); any Ccm2 mutation (42 available)
Map3k3tm1.1Mlkn mutation (0 available); any Map3k3 mutation (16 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• tamoxifen injected mice show full rescue of cerebral cavernous malformation lesion formation (J:232707)
• tamoxifen injected mice do not exhibit cerebral cavernous malformation lesions (J:250906)




Genotype
MGI:6361030
cn6
Allelic
Composition
Nus1tm1.1Qrm/Nus1tm1.1Qrm
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nus1tm1.1Qrm mutation (0 available); any Nus1 mutation (13 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• E10.5 embryos from tamoxifen-treated mothers exhibit aberrant cerebral blood vessel pattering
• E10.5 embryos from tamoxifen-treated mothers have dilated and disrupted organization of blood vessels

embryo
• E01.5 embryos are smaller in size when pregnant females are treated with tamoxifen at E8.5

growth/size/body
• E01.5 embryos are smaller in size when pregnant females are treated with tamoxifen at E8.5

nervous system
• E10.5 embryos from tamoxifen-treated mothers exhibit aberrant cerebral blood vessel pattering




Genotype
MGI:5825525
cn7
Allelic
Composition
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Pfkfb3tm1Pec/Pfkfb3tm1Pec
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation (9 available); any Gt(ROSA)26Sor mutation (745 available)
Pfkfb3tm1Pec mutation (0 available); any Pfkfb3 mutation (24 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice treated with tamoxifen at P1-4 show reduced vascular branching in retinal vessels at P5
• mice treated with tamoxifen at P1-4 show fewer distal sprouts with filopodia and fewer number of filopodia in the retinal vasculature
• distal sprouts have fewer side connections in the retinal vasculature of mice treated with tamoxifen at P1-4
• the radial expansion of the vascular plexus is reduced in mice treated with tamoxifen at P1-4
• vessel regression in the retina is increased in tamoxifen treated mice

cellular
• endothelial cell proliferation is reduced

vision/eye
• mice treated with tamoxifen at P1-4 show reduced vascular branching in retinal vessels at P5
• mice treated with tamoxifen at P1-4 show fewer distal sprouts with filopodia and fewer number of filopodia in the retinal vasculature
• distal sprouts have fewer side connections in the retinal vasculature of mice treated with tamoxifen at P1-4
• the radial expansion of the vascular plexus is reduced in mice treated with tamoxifen at P1-4
• vessel regression in the retina is increased in tamoxifen treated mice




Genotype
MGI:5792803
cn8
Allelic
Composition
Sox17tm2Sjm/Sox17tm2Sjm
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox17tm2Sjm mutation (1 available); any Sox17 mutation (20 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• under prolonged angiotensin II (AT II) infusion, tamoxifen treated mice show luminal dilation, wall thinning, and decreased vascular smooth muscle layers at multiple vascular locations around the distal intracerebral bifurcation of intracerebral arteries
• under AT II infusion, endothelial junctions of intracerebral arteries from tamoxifen treated mice are severely disrupted
• under AT II infusion, intracerebral arteries from tamoxifen treated mice show infrequent focal endothelial denudation
• under moderate AT II infusion, abdominal aorta of tamoxifen treated mice shows a modest decrease in wall thickness but does not show luminal dilation
• under moderate AT II infusion, thoracic aorta of tamoxifen treated mice shows a modest decrease in wall thickness but does not show luminal dilation
• tamoxifen treated mice under AT II infusion occasionally exhibit arterial dissection on the walls of intracranial arteries
• under AT II infusion, endothelial layers in vessels of tamoxifen treated mice exhibit an abnormal lateral morphology with an irregular and flattened shape
• arteries from tamoxifen treated mice have less coverage by vascular smooth muscle cells
• about 25% of tamoxifen treated mice show abnormally enlarged structure with tortuosity resembling fusiform dilation or a balloon-like structure indicative of saccular aneurysm
• 60% of tamoxifen treated mice subjected to a moderate hypertensive condition by infusion with a low dose of angiotensin II (AT II) exhibit features of intracranial aneurysm, showing vascular enlargement of intracerebral arteries, luminal dilation, and wall thinning
• tamoxifen treated mice under AT II infusion frequently exhibit hemorrhage in cerebrospinal fluid, in the intracranial region, and in the intramural region
• hemorrhage is infrequently seen in mutants under steady state conditions
• under AT II infusion, intracerebral arteries from tamoxifen treated mice show increased stress-induced leakage of intravenously infused Evans blue dye

cellular
• AT II-induced endothelial proliferation is suppressed in the vessels of tamoxifen treated mice

muscle
• arteries from tamoxifen treated mice have less coverage by vascular smooth muscle cells




Genotype
MGI:5696330
cn9
Allelic
Composition
Gipc1tm1.1Mhsi/Gipc1tm1.1Mhsi
Tg(Cdh5-cre/ERT2)1Rha/?
Genetic
Background
involves: 129S1/SvImJ * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gipc1tm1.1Mhsi mutation (1 available); any Gipc1 mutation (36 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• reduced number of collateral arteries
• reduced diameter of input arterioles in the spinotrapezius
• significant decline in blood flow recovery after hind limb ischemia




Genotype
MGI:5445987
cn10
Allelic
Composition
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
S1pr1tm2Rlp/S1pr1tm2Rlp
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(EYFP)Cos mutation (9 available); any Gt(ROSA)26Sor mutation (745 available)
S1pr1tm2Rlp mutation (2 available); any S1pr1 mutation (20 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• glomeruloid lesions form when tamoxifen is administered throughout pregnancy, although these lesions are less severe than in germ line null mice
• endothelial hyper-sprouting and retention of mural cell coverage on arteries and veins are detected after tamoxifen treatment

vision/eye
• endothelial hyper-sprouting and retention of mural cell coverage on arteries and veins are detected after tamoxifen treatment




Genotype
MGI:6279217
cn11
Allelic
Composition
Klf2tm1Mlkn/Klf2tm1Mlkn
Krit1tm1Kwhi/Krit1tm1Kwhi
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf2tm1Mlkn mutation (0 available); any Klf2 mutation (10 available)
Krit1tm1Kwhi mutation (0 available); any Krit1 mutation (19 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit 99% rescue of cerebral cavernous malformation lesion formation, with only a small amount of venule dilatation visible




Genotype
MGI:6279218
cn12
Allelic
Composition
Klf4tm1Khk/Klf4+
Krit1tm1Kwhi/Krit1tm1Kwhi
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf4tm1Khk mutation (1 available); any Klf4 mutation (20 available)
Krit1tm1Kwhi mutation (0 available); any Krit1 mutation (19 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• tamoxifen injected mice exhibit a marked (75%) but incomplete prevention of cerebral cavernous malformation lesion formation

nervous system
• tamoxifen injected mice exhibit a marked (75%) but incomplete prevention of cerebral cavernous malformation lesion formation




Genotype
MGI:6279211
cn13
Allelic
Composition
Krit1tm1Kwhi/Krit1tm1Kwhi
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krit1tm1Kwhi mutation (0 available); any Krit1 mutation (19 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• almost all tamoxifen injected mice are dead by P30

cardiovascular system
• vascular malformation are first seen at P6 of tamoxifen injected mice as dilated venules in the cerebellar white matter, with numerous mature lesions present by P11 (J:232707)
• mice injected with tamoxifen at P1 exhibit cerebral cavernous malformation lesions by P13 (J:250906)
• tamoxifen injected mice exhibit dilated venules in the cerebellar white matter

nervous system
• vascular malformation are first seen at P6 of tamoxifen injected mice as dilated venules in the cerebellar white matter, with numerous mature lesions present by P11 (J:232707)
• mice injected with tamoxifen at P1 exhibit cerebral cavernous malformation lesions by P13 (J:250906)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cerebral cavernous malformation DOID:0060669 J:232707 , J:250906




Genotype
MGI:6279216
cn14
Allelic
Composition
Klf2tm1Mlkn/Klf2+
Krit1tm1Kwhi/Krit1tm1Kwhi
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf2tm1Mlkn mutation (0 available); any Klf2 mutation (10 available)
Krit1tm1Kwhi mutation (0 available); any Krit1 mutation (19 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• tamoxifen injected mice exhibit a marked (80%) but incomplete prevention of cerebral cavernous malformation lesion formation

nervous system
• tamoxifen injected mice exhibit a marked (80%) but incomplete prevention of cerebral cavernous malformation lesion formation




Genotype
MGI:6279215
cn15
Allelic
Composition
Krit1tm1Kwhi/Krit1tm1Kwhi
Map3k3tm1.1Mlkn/Map3k3+
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6NCrl * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krit1tm1Kwhi mutation (0 available); any Krit1 mutation (19 available)
Map3k3tm1.1Mlkn mutation (0 available); any Map3k3 mutation (16 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• tamoxifen injected mice show a reduction in the number and size of vascular lesions in the brain at P11, with nearly complete prevention of lesions




Genotype
MGI:6361104
cn16
Allelic
Composition
Nus1tm1Wcsa/Nus1+
Rtn4tm1Matl/Rtn4tm1Matl
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nus1tm1Wcsa mutation (0 available); any Nus1 mutation (13 available)
Rtn4tm1Matl mutation (1 available); any Rtn4 mutation (118 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• embryos from tamoxifen-treated pregnant females at E8.5 do not show vascular defects




Genotype
MGI:6723729
cn17
Allelic
Composition
Amotl1tm1Laho/Amotl1tm1Laho
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amotl1tm1Laho mutation (0 available); any Amotl1 mutation (31 available)
Gt(ROSA)26Sortm1(EYFP)Cos mutation (9 available); any Gt(ROSA)26Sor mutation (745 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• pups injected with tamoxifen at P1-P3 show abnormal pericyte morphology, with mural cells "bulging out" from blood vessels, in P6 retinas
• pups injected with tamoxifen at P1-P3 show a decreased density of the vessel network covering a smaller area of the retina at P6; the vascular density and number of branching points are significantly lower in the periphery and center of P6 retinas
• however, mice injected with tamoxifen at an adult stage show no alterations in the number of branching points and vascular density in adult retinas
• pups injected with tamoxifen at P1-P3 show a small but significant reduction in the number of tip cells per vessel length and abnormal pericyte morphology resulting in decreased pericyte coverage of blood vessels in P6 retinas
• however, the number of filopodia per tip cell is relatively normal at P6

vision/eye
• pups injected with tamoxifen at P1-P3 show a decreased density of the vessel network covering a smaller area of the retina at P6; the vascular density and number of branching points are significantly lower in the periphery and center of P6 retinas
• however, mice injected with tamoxifen at an adult stage show no alterations in the number of branching points and vascular density in adult retinas
• pups injected with tamoxifen at P1-P3 show a small but significant reduction in the number of tip cells per vessel length and abnormal pericyte morphology resulting in decreased pericyte coverage of blood vessels in P6 retinas
• however, the number of filopodia per tip cell is relatively normal at P6




Genotype
MGI:6121066
cn18
Allelic
Composition
Amotl2tm1.1Laho/Amotl2+
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amotl2tm1.1Laho mutation (0 available); any Amotl2 mutation (40 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• embryo aortic endothelial cells shaped short and rounded
• in 80% of E9.5 embryos
• embryo aortic endothelial cells shaped short and rounded




Genotype
MGI:6121065
cn19
Allelic
Composition
Amotl2tm1.1Laho/Amotl2tm1.1Laho
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amotl2tm1.1Laho mutation (0 available); any Amotl2 mutation (40 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• postnatal retinal angiogenesis
• embryo aortic endothelial cells shaped short and rounded
• in 80% of E9.5 embryos
• embryo aortic endothelial cells shaped short and rounded
• endothelium of embryo posterior cardinal vein (PCV), intersegmental vessels (ISVs) and brain vascular plexus




Genotype
MGI:5297596
cn20
Allelic
Composition
Pdcd10tm1Arte/Pdcd10tm1Arte
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd10tm1Arte mutation (0 available); any Pdcd10 mutation (17 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice injected with tamoxifen at P1 develop cerebral cavernous malformation lesions within the cerebellum
• mice injected with tamoxifen at P1 develop cerebral cavernous malformation lesions within the periphery of the retina

nervous system
• mice injected with tamoxifen at P1 develop cerebral cavernous malformation lesions within the cerebellum

vision/eye
• mice injected with tamoxifen at P1 develop cerebral cavernous malformation lesions within the periphery of the retina




Genotype
MGI:5297595
cn21
Allelic
Composition
Krit1tm1Arte/Krit1tm1Arte
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krit1tm1Arte mutation (0 available); any Krit1 mutation (19 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice injected with tamoxifen at P1 develop cerebral cavernous malformation lesions within the cerebellum
• mice injected with tamoxifen at P1 develop cerebral cavernous malformation lesions within the periphery of the retina

nervous system
• mice injected with tamoxifen at P1 develop cerebral cavernous malformation lesions within the cerebellum

vision/eye
• mice injected with tamoxifen at P1 develop cerebral cavernous malformation lesions within the periphery of the retina




Genotype
MGI:6514412
cn22
Allelic
Composition
Lypla1tm1Sem/Lypla1tm1Sem
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lypla1tm1Sem mutation (0 available); any Lypla1 mutation (129 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice treated with tamoxifen show decreased hindlimb perfusion recovery after femoral artery ligation (model of peripheral artery disease), with reduced arterial expansion indication decreased arteriogenesis
• tamoxifen-treated mice subjected to femoral artery ligation show decreased pericyte coverage of microvascular networks and decreased numbers of both capillaries and pericytes, indicating decreased angiogenesis
• 2 weeks after femoral artery ligation, fibronectin is increased in the intima, but not the media, of lower extremity arteries compared to controls




Genotype
MGI:6723732
cn23
Allelic
Composition
Amotl1tm1Laho/Amotl1tm1Laho
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amotl1tm1Laho mutation (0 available); any Amotl1 mutation (31 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells exhibit a significant increase in tumor blood vessel diameter relative to control mice
• however, tumor weight of LLC tumors is not significantly altered

neoplasm
• tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells exhibit a significant increase in tumor blood vessel diameter relative to control mice
• however, tumor weight of LLC tumors is not significantly altered




Genotype
MGI:5608673
cn24
Allelic
Composition
Rhojtm1.1Auem/Rhojtm1.1Auem
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: C57BL/6 * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhojtm1.1Auem mutation (0 available); any Rhoj mutation (10 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• decrease in vascular densities in peri- and intratumoral areas, decreased pericyte and basement membrane coverage and increased vascular permeability in tumors formed by injection of Lewis lung carcinoma cells
• tumors formed by injection of Lewis lung carcinoma cells show an increase in hemorrhagic necrosis
• decreased growth of injected Lewis lung carcinoma cells
• decrease in growth is less than in mice with a germ line deletion of Rhoj

cardiovascular system
• decrease in vascular densities in peri- and intratumoral areas, decreased pericyte and basement membrane coverage and increased vascular permeability in tumors formed by injection of Lewis lung carcinoma cells
• tumors formed by injection of Lewis lung carcinoma cells show an increase in hemorrhagic foci




Genotype
MGI:6723730
cn25
Allelic
Composition
Amotl1tm1Laho/Amotl1tm1Laho
Tg(Cdh5-cre/ERT2)1Rha/0
Tg(MMTV-PyVT)634Mul/0
Genetic
Background
involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amotl1tm1Laho mutation (0 available); any Amotl1 mutation (31 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice injected with tamoxifen show significantly enlarged and dilated infiltrating blood vessels in the mammary tumor area relative to control mice, as determined by vessel diameter
• however, adult retinal vessels from these mice exhibit no changes in vessel diameter

neoplasm
• mice injected with tamoxifen show significantly enlarged and dilated infiltrating blood vessels in the mammary tumor area relative to control mice, as determined by vessel diameter
• however, adult retinal vessels from these mice exhibit no changes in vessel diameter
• mice injected with tamoxifen exhibit a longer lag time until mammary gland tumors are detected relative to control mice
• however, overall tumor progression is not affected




Genotype
MGI:6415692
cn26
Allelic
Composition
Flvcr2tm1.1Tda/Flvcr2tm1.2Tda
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flvcr2tm1.1Tda mutation (0 available); any Flvcr2 mutation (14 available)
Flvcr2tm1.2Tda mutation (0 available); any Flvcr2 mutation (14 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• tamoxifen-treated mice exhibit normal blood brain barrier function




Genotype
MGI:6415689
cn27
Allelic
Composition
Flvcr2tm1.1Tda/Flvcr2tm1.1Tda
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flvcr2tm1.1Tda mutation (0 available); any Flvcr2 mutation (14 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• tamoxifen-treated mice exhibit normal blood brain barrier function
• in response to supra-physiologic levels of VEGF, endothelial cells from tamoxifen-treated embryos exhibit reduced ability to adopt a tip cell phenotype compared with control cells

cellular
• in cells from tamoxifen-treated embryos in response to supra-physiologic levels of VEGF




Genotype
MGI:6364849
cn28
Allelic
Composition
Sdc2tm1c(KOMP)Wtsi/Sdc2tm1c(KOMP)Wtsi
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdc2tm1c(KOMP)Wtsi mutation (0 available); any Sdc2 mutation (11 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• induced by VEGFA165 in retinal from tamoxifen-treated mice in a cornea pocket assay model
• however, response to FGF2 is normal

homeostasis/metabolism
• reduced blood flow after common femoral artery ligation with reduced perfused arterial vessels and vessel size in tamoxifen-treated mice




Genotype
MGI:5470092
cn29
Allelic
Composition
Pfn1tm1Foxp/Pfn1tm1Foxp
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pfn1tm1Foxp mutation (0 available); any Pfn1 mutation (6 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• after ischemia, tamoxifen-treated mice exhibit impaired angiogenesis and reduced perfusion compared with control mice




Genotype
MGI:5445989
cn30
Allelic
Composition
Cdh5tm1Dvst/Cdh5tm1Dvst
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh5tm1Dvst mutation (0 available); any Cdh5 mutation (34 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• prominent endothelial hyper-sprouting
• detaching tip cells have poor cellular connections to the vascular plexus at the angiogenic front and show signs of increased motility

vision/eye
• prominent endothelial hyper-sprouting
• detaching tip cells have poor cellular connections to the vascular plexus at the angiogenic front and show signs of increased motility




Genotype
MGI:5771679
cn31
Allelic
Composition
Cpt1atm1.1Pec/Cpt1atm1.1Pec
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpt1atm1.1Pec mutation (0 available); any Cpt1a mutation (38 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice injected with tamoxifen at P1-P4 exhibit a reduced number of vascular branch points and reduced radial expansion of the vascular plexus at P5, as shown by isolectin-B4 staining of retinal vessels
• vascular sprouting defects are due to impaired endothelial cell proliferation
• no increase in retinal vessel regression or changes in filopodia number or vessel maturation are observed
• mice injected with tamoxifen at P1-P4 exhibit reduced endothelial cell proliferation in retinal vessels at P5, as shown by EdU staining

cellular
• mice injected with tamoxifen at P1-P4 exhibit reduced endothelial cell proliferation in retinal vessels at P5, as shown by EdU staining

vision/eye
• mice injected with tamoxifen at P1-P4 exhibit a reduced number of vascular branch points and reduced radial expansion of the vascular plexus at P5, as shown by isolectin-B4 staining of retinal vessels
• vascular sprouting defects are due to impaired endothelial cell proliferation
• no increase in retinal vessel regression or changes in filopodia number or vessel maturation are observed




Genotype
MGI:6361095
cn32
Allelic
Composition
Nus1tm1Wcsa/Nus1tm1Wcsa
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nus1tm1Wcsa mutation (0 available); any Nus1 mutation (13 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• embryos from tamoxifen-treated females at E8.5 and E9.5 exhibit subcutaneous edema

mortality/aging
• embryos from tamoxifen-treated females at E8.5 and E9.5 die 5 days after tamoxifen injection

embryo
• yolk sacs show vascular defects in embryos from tamoxifen-treated females at E8.5 and E9.5
• embryos from tamoxifen-treated females at E8.5 and E9.5 show blood filled jugular lymph sacs at E13.5

cardiovascular system
• embryos from tamoxifen-treated females at E8.5 and E9.5 show dilation of subcutaneous microvessels and blood filled jugular lymph sacs at E13.
• reduction in vascular density and disorganized vascular networks are seen in embryonic tissues (hindbrain, skin, and hindlimb) of embryos from tamoxifen-treated females at E8.5 and E9.5
• yolk sacs show vascular defects in embryos from tamoxifen-treated females at E8.5 and E9.5
• embryos from tamoxifen-treated females at E8.5 and E9.5 exhibit extensive multifocal subcutaneous hemorrhages at E12.5 and E13.5
• dorsal skin of embryos from tamoxifen-treated females show increased apoptosis

cellular
• dorsal skin of embryos from tamoxifen-treated females show increased apoptosis
• embryos from tamoxifen-treated females at E8.5 and E9.5 show 48% reductions in endothelial cell proliferation at E12.5

homeostasis/metabolism
• embryos from tamoxifen-treated females at E8.5 and E9.5 exhibit subcutaneous edema

immune system
• embryos from tamoxifen-treated females at E8.5 and E9.5 show blood filled jugular lymph sacs at E13.5





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory