Mouse Genome Informatics
hm1
     Glis3tm1Amj/Glis3tm1Amj
involves: 129/Sv * C57BL/6
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
mortality/aging
complete postnatal lethality ( J:148994 )
• mice die by P12

renal/urinary system
increased glomerular capsule space ( J:148994 )
• between E14.5 and E15.5, Bowman's spaces are dilated unlike in wild-type mice
abnormal renal tubule epithelial cell primary cilium morphology ( J:148994 )
• dilated tubules exhibit a reduction in cilium lining compared with wild-type tubules
dilated renal tubules ( J:148994 )
• dilated tubules exhibit a reduction in cilium lining compared with wild-type tubules
polycystic kidney ( J:148994 )
• at P3, mice develop tubular and glomerular cysts unlike wild-type mice
• polycystic kidney disease worsens with age
• cysts originate from the glomeruli, tubules, and collecting ducts
• cell proliferation of the glomerulocyst epithelium lining is increased compared to the proliferation of wild-type Bowman's space lining
• cysts exhibit a reduction in cilium lining compared to in wild-type renal linings

homeostasis/metabolism
hyperglycemia ( J:148994 )
• in neonates due to a deficiency in the generation of pancreatic beta-cells
increased circulating insulin level ( J:148994 )
• in neonates due to a deficiency in the generation of pancreatic beta-cells

growth/size