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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Glis3tm1Amj
targeted mutation 1, Anton M Jetten
MGI:3848053
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Glis3tm1Amj/Glis3tm1Amj involves: 129/Sv * C57BL/6 MGI:3848057


Genotype
MGI:3848057
hm1
Allelic
Composition
Glis3tm1Amj/Glis3tm1Amj
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glis3tm1Amj mutation (0 available); any Glis3 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die by P12 (J:148994)
• mice die by P12 (J:148994)

renal/urinary system
• dilated tubules exhibit a reduction in cilium lining compared with wild-type tubules (J:148994)
• dilated tubules exhibit a reduction in cilium lining compared with wild-type tubules (J:148994)
• between E14.5 and E15.5, Bowman's spaces are dilated unlike in wild-type mice (J:148994)
• between E14.5 and E15.5, Bowman's spaces are dilated unlike in wild-type mice (J:148994)
• dilated tubules exhibit a reduction in cilium lining compared with wild-type tubules (J:148994)
• dilated tubules exhibit a reduction in cilium lining compared with wild-type tubules (J:148994)
• at P3, mice develop tubular and glomerular cysts unlike wild-type mice (J:148994)
• polycystic kidney disease worsens with age (J:148994)
• cysts originate from the glomeruli, tubules, and collecting ducts (J:148994)
• cell proliferation of the glomerulocyst epithelium lining is increased compared to the proliferation of wild-type Bowman's space lining (J:148994)
• cysts exhibit a reduction in cilium lining compared to in wild-type renal linings (J:148994)
• at P3, mice develop tubular and glomerular cysts unlike wild-type mice (J:148994)
• polycystic kidney disease worsens with age (J:148994)
• cysts originate from the glomeruli, tubules, and collecting ducts (J:148994)
• cell proliferation of the glomerulocyst epithelium lining is increased compared to the proliferation of wild-type Bowman's space lining (J:148994)
• cysts exhibit a reduction in cilium lining compared to in wild-type renal linings (J:148994)

homeostasis/metabolism
• in neonates due to a deficiency in the generation of pancreatic beta-cells (J:148994)
• in neonates due to a deficiency in the generation of pancreatic beta-cells (J:148994)
• in neonates due to a deficiency in the generation of pancreatic beta-cells (J:148994)
• in neonates due to a deficiency in the generation of pancreatic beta-cells (J:148994)

growth/size/body
• 10% at P0 (J:148994)
• 10% at P0 (J:148994)

cellular
• dilated tubules exhibit a reduction in cilium lining compared with wild-type tubules (J:148994)
• dilated tubules exhibit a reduction in cilium lining compared with wild-type tubules (J:148994)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Neonatal, with Congenital Hypothyroidism 610199 J:148994





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory