Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SERPINA1*E342K)#Slcw mutation
(1 available)
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homeostasis/metabolism
liver/biliary system
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• mice show liver fibrosis around 4 months of age
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SERPINA1*E342K)#Slcw mutation
(1 available)
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liver/biliary system
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• multiple small foci of necrosis are present in the liver and these areas show fragmentation of hepatocytes and globules
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• clusters of leukocytes are associated with foci of necrosis and leukocytic infiltrates are seen occasionally in portal tracts and in surrounding terminal hepatic veins
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• hepatocytes exhibit numerous cytoplasmic globular inclusions
(J:149132)
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immune system
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• clusters of leukocytes are associated with foci of necrosis and leukocytic infiltrates are seen occasionally in portal tracts and in surrounding terminal hepatic veins
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homeostasis/metabolism
cellular
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• multiple small foci of necrosis are present in the liver and these areas show fragmentation of hepatocytes and globules
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