Phenotypes associated with this allele

• Allele Symbol: Tg(SERPINA1*E342K)#Slcw
• Allele Name: transgene insertion, Savio L C Woo
• Allele ID: MGI:3847801
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(SERPINA1*E342K)#Slcw/Tg(SERPINA1*E342K)#Slcw	involves: C57BL/6 * ICR	MGI:5562921
tg2	Tg(SERPINA1*E342K)#Slcw/0	involves: C57BL/6 * ICR	MGI:5562546

Genotype
MGI:5562921

tg1

• Allelic Composition: Tg(SERPINA1*E342K)#Slcw/Tg(SERPINA1*E342K)#Slcw
• Genetic Background: involves: C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal enzyme/coenzyme level ( J:208016 )

• mice show elevations in liver enzymes such as alanine transaminase and aspartate aminotransferase

liver/biliary system

liver fibrosis ( J:208016 )

• mice show liver fibrosis around 4 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alpha 1-antitrypsin deficiency		DOID:13372	OMIM:613490	J:208016

Genotype
MGI:5562546

tg2

• Allelic Composition: Tg(SERPINA1*E342K)#Slcw/0
• Genetic Background: involves: C57BL/6 * ICR

liver/biliary system

hepatic necrosis ( J:149132 )

• multiple small foci of necrosis are present in the liver and these areas show fragmentation of hepatocytes and globules

liver inflammation ( J:149132 )

• clusters of leukocytes are associated with foci of necrosis and leukocytic infiltrates are seen occasionally in portal tracts and in surrounding terminal hepatic veins

abnormal hepatocyte morphology ( J:149132 , J:208016 )

• hepatocytes exhibit numerous cytoplasmic globular inclusions (J:149132)

immune system

liver inflammation ( J:149132 )

• clusters of leukocytes are associated with foci of necrosis and leukocytic infiltrates are seen occasionally in portal tracts and in surrounding terminal hepatic veins

homeostasis/metabolism

abnormal enzyme/coenzyme level ( J:208016 )

• young mice show mild elevations in liver enzymes such as alanine transaminase and aspartate aminotransferase

cellular

hepatic necrosis ( J:149132 )

• multiple small foci of necrosis are present in the liver and these areas show fragmentation of hepatocytes and globules