Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp7tm1.1Dgra mutation
(0 available);
any
Bmp7 mutation
(21 available)
|
|
|
normal phenotype
|
|
• mice are indistinguishable from wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp7tm1.1Dgra mutation
(0 available);
any
Bmp7 mutation
(21 available)
H2az2Tg(Wnt1-cre)11Rth mutation
(2 available);
any
H2az2 mutation
(23 available)
|
|
|
mortality/aging
|
|
• starting at around 3 weeks of age, mice show a failure to thrive with variable onset that leads to death, with only 30% of mice surviving past 8 weeks of age
|
behavior/neurological
|
|
• mice show decreased exercise capacity at P30, with mice tiring very quickly in an acute speed test and spending more time on the resting plate
|
craniofacial
|
|
• mice exhibit a more acutely angled cranial base at 4 weeks of age but not at P14 or P21
|
|
|
• mice present with a shorter, more acute-angled cranial base
|
|
|
• lengths of the posterior and anterior frontal complex are reduced
|
|
|
• 4-week old mice exhibit a shorter basispenoid which is not seen at P14 or P21
• however, lengths of basioccipital, presphenoid, and ethmoid bones are not changed
|
|
|
• mice show increased frontal bossing and a change to frontal bossing angle at 1 month of age
|
|
|
• mice show depressed nasal bones and changes to nasal depression angle at 1 month of age
|
|
|
• length, but not width, of the nasal bones is reduced
|
|
|
• turbinate development appears disturbed, with reduced branching and ossification, and slight swelling of turbinate soft tissue bilaterally at P14; swelling and reduced turbinate branching are more noticeable at P30
|
|
|
• difference in facial length becomes significant at P21 due to reduced facial growth between the 2- and 3-week time points
|
|
|
• nasal airway obstruction
|
|
|
• all mice develop nasal septum deviation by P30, with variable extent, shape, direction and location and degree of deviation
|
|
|
• mice show a more acute-angled snout at 1 month of age
|
|
|
• mice show a midfacial depression of varying degree from about 2 weeks of age and develop midfacial hypoplasia that becomes prominent around P21
|
growth/size/body
|
|
• mice show increased frontal bossing and a change to frontal bossing angle at 1 month of age
|
|
|
• turbinate development appears disturbed, with reduced branching and ossification, and slight swelling of turbinate soft tissue bilaterally at P14; swelling and reduced turbinate branching are more noticeable at P30
|
|
|
• difference in facial length becomes significant at P21 due to reduced facial growth between the 2- and 3-week time points
|
|
|
• nasal airway obstruction
|
|
|
• all mice develop nasal septum deviation by P30, with variable extent, shape, direction and location and degree of deviation
|
|
|
• mice show a more acute-angled snout at 1 month of age
|
|
|
• mice show a midfacial depression of varying degree from about 2 weeks of age and develop midfacial hypoplasia that becomes prominent around P21
|
homeostasis/metabolism
respiratory system
|
|
• turbinate development appears disturbed, with reduced branching and ossification, and slight swelling of turbinate soft tissue bilaterally at P14; swelling and reduced turbinate branching are more noticeable at P30
|
|
|
• nasal airway obstruction
|
|
|
• all mice develop nasal septum deviation by P30, with variable extent, shape, direction and location and degree of deviation
|
|
|
• short respiratory disruptions following a sigh is reduced, whereas prolonged post-sigh events (more than or two apneas following a sigh) are increased
• majority of respiratory disturbances develop following the development of craniofacial abnormalities
|
|
|
• mice with apneas exhibit a lower baseline respiratory frequency and an increase in cycle duration of each respiratory event due to an increase in the inspiratory time
|
|
|
• plethysmopgraphy shows that 50% of mice elicit a greater number of spontaneous apneas in normoxia
• presence of greater number of spontaneous apneas persists during hypoxia, as well as during the first minute of recovery to normoxia
• however, the presence of greater number of spontaneous apneas disappears during hyperoxia
|
skeleton
|
|
• mice exhibit a more acutely angled cranial base at 4 weeks of age but not at P14 or P21
|
|
|
• mice present with a shorter, more acute-angled cranial base
|
|
|
• lengths of the posterior and anterior frontal complex are reduced
|
|
|
• 4-week old mice exhibit a shorter basispenoid which is not seen at P14 or P21
• however, lengths of basioccipital, presphenoid, and ethmoid bones are not changed
|
|
|
• mice show increased frontal bossing and a change to frontal bossing angle at 1 month of age
|
|
|
• mice show depressed nasal bones and changes to nasal depression angle at 1 month of age
|
|
|
• length, but not width, of the nasal bones is reduced
|
|
|
• turbinate development appears disturbed, with reduced branching and ossification, and slight swelling of turbinate soft tissue bilaterally at P14; swelling and reduced turbinate branching are more noticeable at P30
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp7tm1.1Dgra mutation
(0 available);
any
Bmp7 mutation
(21 available)
Tg(Prrx1-cre)1Cjt mutation
(2 available)
|
|
|
immune system
|
|
• slight increase in accumulation of F4/80+ macrophages in the synovial membrane at 4 weeks of age which increases significantly with age, indicating sinovits
|
|
|
• mice show articular cartilage degeneration after 8 weeks of age
|
skeleton
|
|
• slight increase in accumulation of F4/80+ macrophages in the synovial membrane at 4 weeks of age which increases significantly with age, indicating sinovits
|
|
|
• mice show articular cartilage degeneration after 8 weeks of age
|
|
|
• loss of proteoglycan and aggrecan content in articular cartilage at 8 weeks of age which is severe at 24 weeks
|
|
|
• extensive synovial hyperplasia at 8 and 24 weeks of age
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm4Blh mutation
(0 available);
any
Bmp4 mutation
(17 available)
Bmp7tm1.1Dgra mutation
(0 available);
any
Bmp7 mutation
(21 available)
Hoxa3tm1(cre)Moon mutation
(1 available);
any
Hoxa3 mutation
(21 available)
|
|
|
digestive/alimentary system
embryo
limbs/digits/tail
renal/urinary system
Analysis Tools