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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(SMN2*A111G)591Ahmb
transgene insertion 591, Arthur H M Burghes
MGI:3847326
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Smn1tm1Msd/Smn1tm1Msd
Tg(SMN2*A111G)591Ahmb/0 		involves: 129P2/OlaHsd * FVB/N MGI:3847438
cx2
 		Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7+
Tg(SMN2*A111G)591Ahmb/0 		involves: 129P2/OlaHsd * FVB/N MGI:3847439
cx3
 		Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Tg(SMN2*A111G)591Ahmb/0 		involves: 129P2/OlaHsd * FVB/N MGI:3847441
cx4
 		Smn1tm1Msd/Smn1tm1Msd
Tg(SMN1*A2G)2023Ahmb/0
Tg(SMN2*A111G)591Ahmb/0 		involves: 129P2/OlaHsd * FVB/N MGI:3847565


Genotype
MGI:3847438
cx1
Allelic
Composition		 Smn1tm1Msd/Smn1tm1Msd
Tg(SMN2*A111G)591Ahmb/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1tm1Msd mutation (37 available); any Smn1 mutation (86 available)
Tg(SMN2*A111G)591Ahmb mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:148541 )
• no animals of this genotype are observed at birth




Genotype
MGI:3847439
cx2
Allelic
Composition		 Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7+
Tg(SMN2*A111G)591Ahmb/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm7Tg(SMN2)89Ahmb mutation (35 available); any Grm7 mutation (124 available)
Smn1tm1Msd mutation (37 available); any Smn1 mutation (86 available)
Tg(SMN2*A111G)591Ahmb mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:148541 )
N
• mice survive over a year (some up to 1.5 years) compared to mutants not carrying the Tg(SMN2*A111G)591Ahmb transgene which have a median survival of 4.4-5 days




Genotype
MGI:3847441
cx3
Allelic
Composition		 Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Tg(SMN2*A111G)591Ahmb/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm7Tg(SMN2)89Ahmb mutation (35 available); any Grm7 mutation (124 available)
Smn1tm1Msd mutation (37 available); any Smn1 mutation (86 available)
Tg(SMN2*A111G)591Ahmb mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:148541 )
N
• mice survive over a year (some up to 1.5 years) compared to mutants not carrying the Tg(SMN2*A111G)591Ahmb transgene which have a median survival of 4.4-5 days




Genotype
MGI:3847565
cx4
Allelic
Composition		 Smn1tm1Msd/Smn1tm1Msd
Tg(SMN1*A2G)2023Ahmb/0
Tg(SMN2*A111G)591Ahmb/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1tm1Msd mutation (37 available); any Smn1 mutation (86 available)
Tg(SMN1*A2G)2023Ahmb mutation (3 available)
Tg(SMN2*A111G)591Ahmb mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:148541 )
• no animals of this genotype are observed at birth, indicating that the two missense SMN alleles cannot complement one another to form a functional complex and rescue the Smn1 deficiency




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory