All Phenotypes Nelfb<tm1.2Roli> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nelfb^tm1.2Roli
targeted mutation 1.2, Rong Li
MGI:3846131

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nelfb^tm1.2Roli/Nelfb^tm1.2Roli	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:3846183
cx2	Nelfb^tm1.2Roli/Nelfb^tm1.2Roli Trp53^tm1Brd/Trp53⁺	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:3846184
cx3	Nelfb^tm1.2Roli/Nelfb^tm1.2Roli Trp53^tm1Brd/Trp53^tm1Brd	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:3846186

Allelic Composition	Nelfb^tm1.2Roli/Nelfb^tm1.2Roli
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nelfb^tm1.2Roli mutation (0 available); any Nelfb mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

No Nelfb^tm1.2Roli/Nelfb^tm1.2Roli embryos develop beyond E5

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:148508 )

• mice begin to die at E6 and all but one mouse die by E13.5

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:148508 )

• mice begin to die at E6

embryo

embryonic growth arrest ( J:148508 )

• mice do not develop beyond E5

abnormal blastocyst morphology ( J:148508 )

• in culture, blastocysts produce abnormal outgrowths with defective or no inner cell mass derivatives

absent inner cell mass ( J:148508 )

• blastocysts fail to form an inner cell mass in culture

• however, cell proliferation in culture is normal

Allelic Composition	Nelfb^tm1.2Roli/Nelfb^tm1.2Roli Trp53^tm1Brd/Trp53⁺
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nelfb^tm1.2Roli mutation (0 available); any Nelfb mutation (24 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:148508 )

• no viable mice are produced

Allelic Composition	Nelfb^tm1.2Roli/Nelfb^tm1.2Roli Trp53^tm1Brd/Trp53^tm1Brd
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:148508 )

• no viable mice are produced

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23