Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Surf1tm1Zev mutation
(0 available);
any
Surf1 mutation
(14 available)
Tg(Ckm-Ppargc1a)31Brsp mutation
(1 available)
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cellular
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• mitochondria in muscle cells exhibit increased cellular respiration compared with wild-type cells
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• muscle cells contain increased mitochondrial DNA compared with control cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ckm-Ppargc1a)31Brsp mutation
(1 available)
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muscle
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• most muscles in transgenic animals display a red color characteristic of oxidative muscle; in contrast, control muscles are paler in appearance
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• muscles in mutant animals are able to sustain a longer duration of continuous contraction; isolated extensor digitorum longus (EDL) muscles show much greater fatigue resistance compared to control muscle
• muscle fiber diameter loss in response to denervation and fasting is less severe in transgenic animals when compared to controls
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behavior/neurological
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• following 5 weeks of a chronic mild stress (CMS) protocol, transgenic mice do not exhibit the increased immobility in forced swim test or decreased sucrose consumption that is observed in wild-type mice
• however, transgenic mice exhibit decreases in body weight similar to wild-type
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ckm-Ppargc1a)31Brsp mutation
(1 available)
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cellular
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• mitochondria in muscle cells exhibit increased cellular respiration compared with wild-type cells
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• muscle cells contain increased mitochondrial DNA compared with control cells
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Analysis Tools