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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
RhoTvrm4
translational research vision model 4
MGI:3845397
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
RhoTvrm4/Rho+ B6.Cg-RhoTvrm4/Pjn MGI:4455025
cx2
RhoTvrm4/Rho+
Rpe65rd12/Rpe65rd12
B6.Cg-Rpe65rd12 RhoTvrm4 MGI:4455027


Genotype
MGI:4455025
ht1
Allelic
Composition
RhoTvrm4/Rho+
Genetic
Background
B6.Cg-RhoTvrm4/Pjn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RhoTvrm4 mutation (2 available); any Rho mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Light-induced degeneration of photoreceptors in RhoTvrm4/Rho+ mice

homeostasis/metabolism
• extracts of whole eyes collected immediately after exposure to 12,000 lux for 5 mins contain significantly lower levels of all trans-retinol than in wild-type
• however, no difference is detected at 1 h after light exposure
• exposure to 12,000 lux of light for 5 min leads to visible bleaching of the entire retina for 1 h following exposure, in contrast wild-type retinas are unaffected
• exposure to 12,000 lux for 2 or more minutes induces photoreceptor degeneration

vision/eye
• TUNEL+ photoreceptors
• exposure to 12,000 lux of light for 5 min leads to visible bleaching of the entire retina for 1 h following exposure, in contrast wild-type retinas are unaffected
• exposure to 12,000 lux for 2 or more minutes induces photoreceptor degeneration
• the border between the outer and inner segments of the retina, and both compartments are highly disorganized 24 h after exposure to 12,000 lux of bright light
• slightly shorter at 1 year of age
• 1 h after exposure to 12,000 lux of bright light, appear disorganized and some areas are devoid of outer segments, whereas others appear to contain outer segment aggregates
• the border between the outer and inner segments of the retina, and both compartments are highly disorganized 24 h after exposure to 12,000 lux of bright light
• bright light-induced degeneration of photoreceptors
• exposure to 12,000 lux for 2 or more minutes induces photoreceptor degeneration
• however, under standard housing conditions no degeneration is detected
• after exposure to 12,000 lux of bright light, apical processes of retinal pigment epithelium that normally ensheath the outer segments appear to extend further along the outer segments than in wild-type
• 24 h after exposure to 12,000 lux of bright light the outer nuclear layer appears disorganized, although cell loss is not apparent
• two or fewer layers of photoreceptor nuclei remaining at 1 week following light exposure
• mice recover with a time constant of 9.5 min and reach an asymptote that is only 60% of the dark adapted value

nervous system
• the border between the outer and inner segments of the retina, and both compartments are highly disorganized 24 h after exposure to 12,000 lux of bright light
• slightly shorter at 1 year of age
• 1 h after exposure to 12,000 lux of bright light, appear disorganized and some areas are devoid of outer segments, whereas others appear to contain outer segment aggregates
• the border between the outer and inner segments of the retina, and both compartments are highly disorganized 24 h after exposure to 12,000 lux of bright light
• bright light-induced degeneration of photoreceptors
• exposure to 12,000 lux for 2 or more minutes induces photoreceptor degeneration
• however, under standard housing conditions no degeneration is detected

pigmentation
• after exposure to 12,000 lux of bright light, apical processes of retinal pigment epithelium that normally ensheath the outer segments appear to extend further along the outer segments than in wild-type

cellular
• TUNEL+ photoreceptors

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 4 DOID:0110372 OMIM:613731
J:159523




Genotype
MGI:4455027
cx2
Allelic
Composition
RhoTvrm4/Rho+
Rpe65rd12/Rpe65rd12
Genetic
Background
B6.Cg-Rpe65rd12 RhoTvrm4
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RhoTvrm4 mutation (2 available); any Rho mutation (38 available)
Rpe65rd12 mutation (1 available); any Rpe65 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Photoreceptor degeneration without exposure to bright light in Rpe65rd12/Rpe65rd12 RhoTvrm4/Rho+ mice

vision/eye
• photoreceptor degeneration without exposure to bright light
• the peripheral retina also shows cell loss but is better preserved than the central retina
• at 4 weeks of age, retinas have only 2-3 rows of cell bodies remaining in the central outer nuclear layer

nervous system
• photoreceptor degeneration without exposure to bright light
• the peripheral retina also shows cell loss but is better preserved than the central retina

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa DOID:10584 OMIM:PS268000
J:159523





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory