Mouse Genome Informatics
ht1
    RhoTvrm1/Rho+
C57BL/6J-RhoTvrm1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Photoreceptor degeneration in RhoTvrm4/Rho+ and RhoTvrm1/Rho+ mutants is rapidly induced by exposure to bright light

vision/eye
• exposure to 12,000 lux of light for only 30 s results in degeneration in 4 of 6 mice
• bright light-induced degeneration of photoreceptors
• exposure to 12,000 lux for 30 or more seconds induces photoreceptor degeneration
• however, under standard housing conditions no degeneration is detected
• mice recover more slowly, with a time constant of 11.5 min and reach an asymptote that falls short of the dark adapted value

homeostasis/metabolism
• in extracts of whole eyes collected immediately after exposure to 12,000 lux for 5 mins a trend is seen toward lower levels of all trans-retinols than in wild-type
• however, no difference is detected at 1 h after light exposure
• exposure to 12,000 lux of light for only 30 s results in degeneration in 4 of 6 mice

nervous system
• bright light-induced degeneration of photoreceptors
• exposure to 12,000 lux for 30 or more seconds induces photoreceptor degeneration
• however, under standard housing conditions no degeneration is detected

Mouse Models of Human Disease
OMIM IDRef(s)
Retinitis Pigmentosa 4; RP4 613731 J:159523


Mouse Genome Informatics
cx2
    RhoTvrm1/Rho+
Rpe65rd12/Rpe65rd12

B6.Cg-Rpe65rd12 RhoTvrm1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
• photoreceptor degeneration without exposure to bright light
• the peripheral retina also shows cell loss but is better preserved than the central retina
• at 4 weeks of age, retinas have only 5 rows of cell bodies remaining in the central outer nuclear layer

nervous system
• photoreceptor degeneration without exposure to bright light
• the peripheral retina also shows cell loss but is better preserved than the central retina

Mouse Models of Human Disease
OMIM IDRef(s)
Retinitis Pigmentosa; RP 268000 J:159523