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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
RhoTvrm1
translational research vision model 1
MGI:3845396
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
RhoTvrm1/Rho+ C57BL/6J-RhoTvrm1 MGI:4455026
cx2
RhoTvrm1/Rho+
Rpe65rd12/Rpe65rd12
B6.Cg-Rpe65rd12 RhoTvrm1 MGI:4455028


Genotype
MGI:4455026
ht1
Allelic
Composition
RhoTvrm1/Rho+
Genetic
Background
C57BL/6J-RhoTvrm1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RhoTvrm1 mutation (0 available); any Rho mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Photoreceptor degeneration in RhoTvrm4/Rho+ and RhoTvrm1/Rho+ mutants is rapidly induced by exposure to bright light

vision/eye
• exposure to 12,000 lux of light for only 30 s results in degeneration in 4 of 6 mice
• bright light-induced degeneration of photoreceptors
• exposure to 12,000 lux for 30 or more seconds induces photoreceptor degeneration
• however, under standard housing conditions no degeneration is detected
• mice recover more slowly, with a time constant of 11.5 min and reach an asymptote that falls short of the dark adapted value

homeostasis/metabolism
• in extracts of whole eyes collected immediately after exposure to 12,000 lux for 5 mins a trend is seen toward lower levels of all trans-retinols than in wild-type
• however, no difference is detected at 1 h after light exposure
• exposure to 12,000 lux of light for only 30 s results in degeneration in 4 of 6 mice

nervous system
• bright light-induced degeneration of photoreceptors
• exposure to 12,000 lux for 30 or more seconds induces photoreceptor degeneration
• however, under standard housing conditions no degeneration is detected

Mouse Models of Human Disease
OMIM ID Ref(s)
Retinitis Pigmentosa 4; RP4 613731 J:159523




Genotype
MGI:4455028
cx2
Allelic
Composition
RhoTvrm1/Rho+
Rpe65rd12/Rpe65rd12
Genetic
Background
B6.Cg-Rpe65rd12 RhoTvrm1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RhoTvrm1 mutation (0 available); any Rho mutation (23 available)
Rpe65rd12 mutation (1 available); any Rpe65 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• photoreceptor degeneration without exposure to bright light
• the peripheral retina also shows cell loss but is better preserved than the central retina
• at 4 weeks of age, retinas have only 5 rows of cell bodies remaining in the central outer nuclear layer

nervous system
• photoreceptor degeneration without exposure to bright light
• the peripheral retina also shows cell loss but is better preserved than the central retina

Mouse Models of Human Disease
OMIM ID Ref(s)
Retinitis Pigmentosa; RP 268000 J:159523





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory