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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hdac2tm1.2Rdp
targeted mutation 1.2, Ronald DePinho
MGI:3844984
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hdac2tm1.2Rdp/Hdac2tm1.2Rdp involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:3844997
cx2
Cdkn2atm2.1Brn/Cdkn2atm2.1Brn
Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5494635
cx3
Cdkn1atm1Led/Cdkn1atm1Led
Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:5494634


Genotype
MGI:3844997
hm1
Allelic
Composition
Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac2tm1.2Rdp mutation (1 available); any Hdac2 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are born with a two-fold lower frequency than expected from a normal Mendelian ratio

behavior/neurological
• mice show markedly increased freezing behaviour as evaluated by the context-dependent and tone-dependent fear conditioning models
• mice also have increased freezing response to short term context-dependent fear conditions

growth/size/body
• male and female mice are about 25% smaller than controls

nervous system
• the number of presynaptic terminals of functional synapses is significantly increased in the CA1 striatum radiatum
• the density of dendritic spines along dentate gyrus granule cells is markedly increased
• the density of dendritic spines along individual dendrites of hippocampal CA1 pyramidal neurons is markedly increased
• robust LTP is readily induced by one train of high frequency stimulation in CA1 neurons whereas wild-type mice require two trains of stimulation

reproductive system
• fertility is compromised in these mice




Genotype
MGI:5494635
cx2
Allelic
Composition
Cdkn2atm2.1Brn/Cdkn2atm2.1Brn
Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm2.1Brn mutation (1 available); any Cdkn2a mutation (41 available)
Hdac2tm1.2Rdp mutation (1 available); any Hdac2 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• cell cycle arrest in mouse embryonic fibroblasts treated with Hdac1 shRNA




Genotype
MGI:5494634
cx3
Allelic
Composition
Cdkn1atm1Led/Cdkn1atm1Led
Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic
Background
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1atm1Led mutation (1 available); any Cdkn1a mutation (48 available)
Hdac2tm1.2Rdp mutation (1 available); any Hdac2 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• senescence-like G1 cell cycle arrest
• senescence-like G1 cell cycle arrest





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory