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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(ACTB-TNFRSF6B)754Jwu
transgene insertion 754 Jiangping Wu
MGI:3843671
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(ACTB-TNFRSF6B)754Jwu/? B6.Cg-Tg(Actb-TNFRSF6B)754Jwu MGI:4361591


Genotype
MGI:4361591
tg1
Allelic
Composition
Tg(ACTB-TNFRSF6B)754Jwu/?
Genetic
Background
B6.Cg-Tg(Actb-TNFRSF6B)754Jwu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTB-TNFRSF6B)754Jwu mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• shortened lifespan is observed mostly in females and transgenic mice with lymphadenopathy (J:148162)
• survival rate for 14 month old females is 63.2% (J:148162)
• survival rate for 14 month old males is 81.8% (J:148162)
• shortened lifespan is observed mostly in females and transgenic mice with lymphadenopathy (J:148162)
• survival rate for 14 month old females is 63.2% (J:148162)
• survival rate for 14 month old males is 81.8% (J:148162)

immune system
• leukocytopenia occurs in 6/10 female transgenic mice older than 6 months of age (J:148162)
• leukocytopenia occurs in 6/10 female transgenic mice older than 6 months of age (J:148162)
• peripheral blood from transgenic mice older than 6 months of age contains a increased percentage of CD4+ T cell exhibiting CD62Llow and CD44high (J:148162)
• peripheral blood from transgenic mice older than 6 months of age contains a increased percentage of CD4+ T cell exhibiting CD62Llow and CD44high (J:148162)
• occurs with lymphadenopathy (J:148162)
• observed in 9 month old mice (J:148162)
• occurs with lymphadenopathy (J:148162)
• observed in 9 month old mice (J:148162)
• transgenic mice exhibit higher concentrations of IgE between 2 and 6 months (J:148162)
• transgenic mice exhibit higher concentrations of IgE between 2 and 6 months (J:148162)
• lymphadenopathy is observed in 6-8 month old mice (J:148162)
• penetrance is higher in females (64.5%) than males (20%) (J:148162)
• usually accompanied by splenomegaly (J:148162)
• lymphadenopathy is observed in 6-8 month old mice (J:148162)
• penetrance is higher in females (64.5%) than males (20%) (J:148162)
• usually accompanied by splenomegaly (J:148162)
• delayed type hypersensitivity reaction is compromised in transgenic mice (J:148162)
• delayed type hypersensitivity reaction is compromised in transgenic mice (J:148162)
• autoantibodies found against mutiple self tissues (liver, lung, kidney, brain) in 7 month old female with lymphadenopathy (J:148162)
• autoantibodies found against mutiple self tissues (liver, lung, kidney, brain) in 7 month old female with lymphadenopathy (J:148162)
• 77% of female and 55% of male transgenic mice are anti-dsDNA antibody positive (J:148162)
• 77% of female and 55% of male transgenic mice are anti-dsDNA antibody positive (J:148162)

hematopoietic system
• observed in female transgenic mice older than 6 months of age (J:148162)
• observed in female transgenic mice older than 6 months of age (J:148162)
• observed in 3/9 female transgenic mice older than 6 months of age (J:148162)
• observed in 3/9 female transgenic mice older than 6 months of age (J:148162)
• leukocytopenia occurs in 6/10 female transgenic mice older than 6 months of age (J:148162)
• leukocytopenia occurs in 6/10 female transgenic mice older than 6 months of age (J:148162)
• peripheral blood from transgenic mice older than 6 months of age contains a increased percentage of CD4+ T cell exhibiting CD62Llow and CD44high (J:148162)
• peripheral blood from transgenic mice older than 6 months of age contains a increased percentage of CD4+ T cell exhibiting CD62Llow and CD44high (J:148162)
• occurs with lymphadenopathy (J:148162)
• observed in 9 month old mice (J:148162)
• occurs with lymphadenopathy (J:148162)
• observed in 9 month old mice (J:148162)
• transgenic mice exhibit higher concentrations of IgE between 2 and 6 months (J:148162)
• transgenic mice exhibit higher concentrations of IgE between 2 and 6 months (J:148162)

homeostasis/metabolism
• mild edema and vasodilation of capillaries and small vessels observed in dermis (J:148162)
• mild edema and vasodilation of capillaries and small vessels observed in dermis (J:148162)

liver/biliary system
• mice older than 6 months of age exhibit periarterial lymphocyte infiltration (J:148162)
• mice older than 6 months of age exhibit periarterial lymphocyte infiltration (J:148162)

renal/urinary system
• IgG and C3 deposition is observed in glomeruli and interstitial spaces (J:148162)
• IgG and C3 deposition is observed in glomeruli and interstitial spaces (J:148162)
• mesangial hypertrophy (J:148162)
• mesangial hypertrophy (J:148162)
• mice older than 6 months of age exhibit enlarged glomeruli with increased glomerular epithelial cellularity and mesangial hypertrophy (J:148162)
• mice older than 6 months of age exhibit enlarged glomeruli with increased glomerular epithelial cellularity and mesangial hypertrophy (J:148162)
• mice older than 6 months of age exhibit renal interstitial fibrosis (J:148162)
• mice older than 6 months of age exhibit renal interstitial fibrosis (J:148162)

integument
• mild edema and vasodilation of capillaries and small vessels observed in dermis (J:148162)
• mild edema and vasodilation of capillaries and small vessels observed in dermis (J:148162)
• area under lesions contains granulomatous tissue consisting of collagen fibers, fibroblasts and infiltration lymphocytes (J:148162)
• mild edema and vasodilation of capillaries and small vessels observed in dermis (J:148162)
• area under lesions contains granulomatous tissue consisting of collagen fibers, fibroblasts and infiltration lymphocytes (J:148162)
• mild edema and vasodilation of capillaries and small vessels observed in dermis (J:148162)
• hyperkeratosis and polymorphonuclear cell infiltration with follicular plugging is found in epidermal lesions (J:148162)
• junction between the epidermis and dermis in unclear (J:148162)
• hyperkeratosis and polymorphonuclear cell infiltration with follicular plugging is found in epidermal lesions (J:148162)
• junction between the epidermis and dermis in unclear (J:148162)
• 40% of 12+ month old females develop lesions (J:148162)
• lesions are characterized by superficial crusting and erosion (J:148162)
• 40% of 12+ month old females develop lesions (J:148162)
• lesions are characterized by superficial crusting and erosion (J:148162)

Mouse Models of Human Disease
OMIM ID Ref(s)
Systemic Lupus Erythematosus; SLE 152700 J:148162





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory