About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CDX2-cre*)189Erf
transgene insertion 189, Eric R Fearon
MGI:3843611
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Apctm1Tno/Apctm1Tno
Tg(CDX2-cre*)189Erf/0
involves: 129S4/SvJae * C57BL/6 * SJL MGI:3844297
cn2
Apctm1Tno/Apc+
Tg(CDX2-cre*)189Erf/0
involves: 129S4/SvJae * C57BL/6 * SJL MGI:3844298


Genotype
MGI:3844297
cn1
Allelic
Composition
Apctm1Tno/Apctm1Tno
Tg(CDX2-cre*)189Erf/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Tno mutation (6 available); any Apc mutation (119 available)
Tg(CDX2-cre*)189Erf mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• animals live only 10-27 days past birth
• animals live only 10-27 days past birth

neoplasm
• some mice show large numbers of polyploid lesions which show dysplastic adenomatous changes upon microscopic analysis
• in proximal colon, tubular adenomatous glands are observed in place of normal mucosa

digestive/alimentary system
• all mice display florid polyposis in the proximal colon and cecum
• some mice show large numbers of polyploid lesions which show dysplastic adenomatous changes upon microscopic analysis
• in proximal colon, tubular adenomatous glands are observed in place of normal mucosa

limbs/digits/tail
• mice often display a short tail
• mice often display a crooked tail




Genotype
MGI:3844298
cn2
Allelic
Composition
Apctm1Tno/Apc+
Tg(CDX2-cre*)189Erf/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Tno mutation (6 available); any Apc mutation (119 available)
Tg(CDX2-cre*)189Erf mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• mice show no signs of disease up to 200 days of age





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/04/2022
MGI 6.17
The Jackson Laboratory