Phenotypes associated with this allele

• Allele Symbol: Tg(Drd2-EGFP)S118Gsat
• Allele Name: transgene insertion S118, GENSAT Project at Rockefeller University
• Allele ID: MGI:3843608
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ppp1r1b^tm5.1Pggd/Ppp1r1b^tm5.1Pggd Tg(Drd2-cre)ER44Gsat/0 Tg(Drd2-EGFP)S118Gsat/0	involves: C57BL/6 * FVB/N * FVB/NTac	MGI:4830460
cx2	Del(7Coro1a-Spn)1Dolm/+ Tg(Drd2-EGFP)S118Gsat/0	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6N * CD-1 * FVB/N	MGI:5571091
cx3	Gprin3^em1Sns/Gprin3^em1Sns Tg(Drd2-EGFP)S118Gsat/0	involves: C57BL/6 * C57BL/6J * CD-1 * FVB/NTac	MGI:6363245

Genotype
MGI:4830460

cn1

• Allelic Composition: Ppp1r1b^tm5.1Pggd/Ppp1r1b^tm5.1Pggd; Tg(Drd2-cre)ER44Gsat/0; Tg(Drd2-EGFP)S118Gsat/0
• Genetic Background: involves: C57BL/6 * FVB/N * FVB/NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

reduced long-term potentiation ( J:163700 )

• loss of expression in striatopallidal and striatonigral neurons results in a reduced LTP at the corticostriatal synapses

behavior/neurological

enhanced behavioral response to cocaine ( J:163700 )

impaired behavioral response to xenobiotic ( J:163700 )

• haloperidol-induced catalepsy is strongly reduced

hyperactivity ( J:163700 )

• in an open-field test

Genotype
MGI:5571091

cx2

• Allelic Composition: Del(7Coro1a-Spn)1Dolm/+; Tg(Drd2-EGFP)S118Gsat/0
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6N * CD-1 * FVB/N

nervous system

abnormal globus pallidus morphology ( J:210018 )

• enlarged globus pallidus at postnatal day 7

abnormal dorsal striatum morphology ( J:210018 )

• increased numbers of Drd2+ cells in ventral and dorsal striatum

abnormal ventral striatum morphology ( J:210018 )

• increased numbers of Drd2+ cells in ventral and dorsal striatum

increased excitatory postsynaptic current frequency ( J:210018 )

• increased excitatory postsynaptic current frequency in Drd2+ medium spiny neurons

Genotype
MGI:6363245

cx3

• Allelic Composition: Gprin3^em1Sns/Gprin3^em1Sns; Tg(Drd2-EGFP)S118Gsat/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CD-1 * FVB/NTac

nervous system

abnormal dendrite morphology ( J:279507 )

♂ • striatonigral medium spiny neurons exhibit reorganization of the dendritic tree without changes in the length of the dendritic segments

♂ • striatopallidal medium spiny neurons exhibit increased dendritic arborization accompanied by a tendency to increase the number of dendritic segments without changes in their length

abnormal nervous system electrophysiology ( J:279507 )

♂ • striatopallidal medium spiny neurons tend to show an increase in cell capacitance, higher resting membrane potential, and overall decreased neuronal excitability

♂ • however, striatonigral medium spiny neurons do not show changes in cell capacitance or in resting membrane potential and cell excitability remains unchanged

♂ • treatment of striatopallidal medium spiny neurons with quinpirole, a D2 receptor agonist, does not modify cell excitability or membrane capacitance as it does in controls

♂ • treatment of striatopallidal medium spiny neurons with quinpirole decreases resting membrane potential