Phenotypes associated with this allele

• Allele Symbol: Tg(KRT5-Akt1*)Jmpa
• Allele Name: transgene insertion, Jesus M Paramio
• Allele ID: MGI:3842829
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rb1^tm2Brn/Rb1^tm2Brn Tg(KRT14-cre)8Brn/0 Tg(KRT5-Akt1*)Jmpa/0	involves: 129 * C57BL/6 * DBA/2 * DBA/2J * FVB/N	MGI:3842836
cn2	Tg(KRT14-cre)8Brn/0 Tg(KRT5-Akt1*)Jmpa/0 Trp53^tm1Brn/Trp53^tm1Brn	involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * DBA/2J * FVB/N	MGI:3842833
tg3	Tg(KRT5-Akt1*)Jmpa/0	involves: C57BL/6 * DBA/2 * DBA/2J * FVB/N	MGI:3842834

Genotype
MGI:3842836

cn1

• Allelic Composition: Rb1^tm2Brn/Rb1^tm2Brn; Tg(KRT14-cre)8Brn/0; Tg(KRT5-Akt1*)Jmpa/0
• Genetic Background: involves: 129 * C57BL/6 * DBA/2 * DBA/2J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:144831 )

• pathologic characteristics of oral lesions and tumor development rate are the same as in Tg(KRT5-Akt1*)Jmpa mice

craniofacial

abnormal oral mucosa morphology ( J:144831 )

• pathologic characteristics of oral lesions and tumor development rate are the same as in Tg(KRT5-Akt1*)Jmpa mice

digestive/alimentary system

abnormal oral mucosa morphology ( J:144831 )

• pathologic characteristics of oral lesions and tumor development rate are the same as in Tg(KRT5-Akt1*)Jmpa mice

growth/size/body

abnormal oral mucosa morphology ( J:144831 )

• pathologic characteristics of oral lesions and tumor development rate are the same as in Tg(KRT5-Akt1*)Jmpa mice

Genotype
MGI:3842833

cn2

• Allelic Composition: Tg(KRT14-cre)8Brn/0; Tg(KRT5-Akt1*)Jmpa/0; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * DBA/2J * FVB/N

neoplasm

abnormal tumor morphology ( J:144831 )

• proliferation is increased in oral tumors compared to in Tg(KRT5-Akt1*)Jmpa oral tumors

• the number of blood vessels is enhanced in dysplasias and tumors compared to normal oral epithelia in Tg(KRT5-Akt1*)Jmpa mice

increased carcinoma incidence ( J:144831 )

• mice develop malignant carcinomas in the oral cavity affecting the palate, ventral side of the tongue, and the external and internal sides of the lips unlike in wild-type mice

• mice develop tumors earlier than in mice expressing Trp53

• mice develop lymph node metastases and lung micrometastases from undifferentiated highly aggressive primary tumors

increased squamous cell carcinoma incidence ( J:144831 )

cellular

increased cell proliferation ( J:144831 )

• cell proliferation of nonlesion oral epithelia is greater than in wild-type and Tg(KRT5-Akt1*)Jmpa mice

increased keratinocyte proliferation ( J:144831 )

• oral keratinocyte proliferation is greater than in wild-type cells

integument

increased keratinocyte proliferation ( J:144831 )

• oral keratinocyte proliferation is greater than in wild-type cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
head and neck squamous cell carcinoma		DOID:5520	OMIM:275355	J:144831

Genotype
MGI:3842834

tg3

• Allelic Composition: Tg(KRT5-Akt1*)Jmpa/0
• Genetic Background: involves: C57BL/6 * DBA/2 * DBA/2J * FVB/N

neoplasm

increased trichoepithelioma incidence ( J:144831 )

• mice exhibit palatine and tongue gland hyperplasia with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma

abnormal tumor morphology ( J:144831 )

• the number of blood vessels is enhanced in dysplasias and tumos compared to normal oral epithelia in Tg(KRT5-Akt1*)Jmpa mice

increased carcinoma incidence ( J:144831 )

• mice exhibit palatine and tongue gland hyperplasia with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma

increased adenocarcinoma incidence ( J:144831 )

• mice exhibit palatine and tongue gland hyperplasia with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma

increased squamous cell carcinoma incidence ( J:144831 )

• in 9 of 33 mice

digestive/alimentary system

abnormal oral mucosa morphology ( J:144831 )

• cell proliferation of nontumoral oral epithelia is mildly increased compared to in wild-type mice

• all mice develop pretumoral lesions in the oral cavity unlike wild-type mice

oral erythroplakia ( J:144831 )

• mice develop erythroplakia in the palate, cheeks, and lips unlike wild-type mice

oral leukoplakia ( J:144831 )

abnormal sublingual gland morphology ( J:144831 )

• hyperplastic with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma

abnormal palatine gland morphology ( J:144831 )

• hyperplastic with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma

cellular

decreased keratinocyte proliferation ( J:144831 )

• oral keratinocyte proliferation is arrested unlike in wild-type cells

increased cell proliferation ( J:144831 )

• cell proliferation of nonlesion oral epithelia is greater than in wild-type mice

craniofacial

abnormal oral mucosa morphology ( J:144831 )

• cell proliferation of nontumoral oral epithelia is mildly increased compared to in wild-type mice

• all mice develop pretumoral lesions in the oral cavity unlike wild-type mice

oral erythroplakia ( J:144831 )

• mice develop erythroplakia in the palate, cheeks, and lips unlike wild-type mice

oral leukoplakia ( J:144831 )

endocrine/exocrine glands

abnormal sublingual gland morphology ( J:144831 )

• hyperplastic with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma

abnormal palatine gland morphology ( J:144831 )

• hyperplastic with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma

integument

decreased keratinocyte proliferation ( J:144831 )

• oral keratinocyte proliferation is arrested unlike in wild-type cells

increased trichoepithelioma incidence ( J:144831 )

• mice exhibit palatine and tongue gland hyperplasia with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma

growth/size/body

abnormal oral mucosa morphology ( J:144831 )

• cell proliferation of nontumoral oral epithelia is mildly increased compared to in wild-type mice

• all mice develop pretumoral lesions in the oral cavity unlike wild-type mice

oral erythroplakia ( J:144831 )

• mice develop erythroplakia in the palate, cheeks, and lips unlike wild-type mice

oral leukoplakia ( J:144831 )