Analysis Tools
liver/biliary system
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• 6 of 7 mice exhibit multiple gray-whitish nodules approximately 1 mm long unlike in wild-type mice
• male mice exhibit coagulative necrosis, sinusoidal dilatation, and congestion in the liver unlike wild-type mice
• 5 of 7 female mice exhibit degenerative changes and perinuclear vacuoles in the liver unlike wild-type mice
• at 9 months, livers exhibit degenerative changes and perinuclear vacuoles unlike in wild-type mice
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• sinusoidal dilatation in male mouse livers
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• sinusoid congestion in male mouse livers
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• coagulative necrosis in male mouse livers
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• at 11 weeks
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• at 4 weeks, 11 weeks, and 9 months, liver weights are increased compared to in wild-type mice
• however, 4 week old mice have normal liver weights
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• 3 of 7 male mice exhibit increased glycogen accumulation in the cytoplasm compared to in wild-type mice
• 5 of 7 female mice exhibit increased glycogen accumulation in the cytoplasm and sinusoids of the liver compared to in wild-type mice
• PAS staining revealed that two-thirds of mice exhibit increased accumulation of liver glycogen levels compared to in wild-type mice
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• at 17 months, mice develop fatty nodules in the liver unlike in wild-type mice
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• degenerative changes are observed in the liver of 5 of 7 female mice
• at 9 months, livers exhibit degenerative changes and perinuclear vacuoles unlike in wild-type mice
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• in 43% of female mice
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• 7 of 7 female mice develop hepatocellular carcinoma (HCC) with a mean age of 20.1 months that are multifocal and in different lobes
• 3 of 6 male mice develop HCC with a mean age of 21.6 months that are unifocal and mainly found in the left hepatic lobe
• at 17 months, mice develop fatty nodules in the liver unlike in wild-type mice
• the mean number of tumor nodules per mouse is 2.3 in male mice and 8 in female mice
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cellular
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• coagulative necrosis in male mouse livers
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homeostasis/metabolism
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• serum methionine levels are 1.9- to 2.4-fold greater than in wild-type mice
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• at 4 weeks, female mice exhibit increased alanine transaminase (ALT) serum levels compared to in wild-type mice
(J:146081)
• at 11 weeks, male and female exhibit increased ALT serum levels compared to in wild-type mice
(J:146081)
• at 4 weeks, female mice exhibit increased alanine transaminase (ALT) serum levels compared to in wild-type mice
(J:147857)
• at 11 weeks, male and female exhibit increased ALT serum levels compared to in wild-type mice
(J:147857)
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• 3 of 7 male mice exhibit increased glycogen accumulation in the cytoplasm compared to in wild-type mice
• 5 of 7 female mice exhibit increased glycogen accumulation in the cytoplasm and sinusoids of the liver compared to in wild-type mice
• PAS staining revealed that two-thirds of mice exhibit increased accumulation of liver glycogen levels compared to in wild-type mice
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growth/size/body
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• at 11 weeks
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• at 4 weeks, 11 weeks, and 9 months, liver weights are increased compared to in wild-type mice
• however, 4 week old mice have normal liver weights
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neoplasm
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• in 43% of female mice
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• 7 of 7 female mice develop hepatocellular carcinoma (HCC) with a mean age of 20.1 months that are multifocal and in different lobes
• 3 of 6 male mice develop HCC with a mean age of 21.6 months that are unifocal and mainly found in the left hepatic lobe
• at 17 months, mice develop fatty nodules in the liver unlike in wild-type mice
• the mean number of tumor nodules per mouse is 2.3 in male mice and 8 in female mice
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immune system
hematopoietic system
cardiovascular system
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• sinusoidal dilatation in male mouse livers
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• sinusoid congestion in male mouse livers
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| glycine N-methyltransferase deficiency | DOID:0111037 |
OMIM:606664 |
J:147857 | |
| hepatocellular carcinoma | DOID:684 |
OMIM:114550 |
J:146081 | |
