Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Cjs mutation
(2 available);
any
Cdkn2a mutation
(62 available)
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neoplasm
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N |
• mice remain phenotypically normal for up to 2 years and are not prone to cancer development
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm3(cre)Cjs mutation
(0 available);
any
Cdkn2a mutation
(62 available)
Cdkn2atm4Cjs mutation
(2 available);
any
Cdkn2a mutation
(62 available)
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vision/eye
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• in one animal with monocular total blindness, lens of blind eye was significantly damaged as well as the retina, while lens and neuroretina of other eye were normal
• in an animal with partial bilateral vision loss, less severe accumulation of retrolental cells with focal attachment to the lens was observed with less severe deformation of the retina compared to animals exhibiting complete blindness
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• retina/lens lesions collectively contribute to gross anatomic micropthalmia in mutants
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• typical lesions observed are aberrant retinal folding, appearance of dysplastic neuroretina detached from pigmented epithelium, and emergence of a fibrotic retrolental mass containing pigmented cells that erodes the posterior lens
• severity of anatomical defects correlates with functional impairment
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• aberrant retinal folding
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• at 5 months of age, animals display varying ocular defects with some animals being totally blind or having partial bilateral vision impairment and some having normal vision;
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vision/eye
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N |
• at 3 months of age, all mutants have normal visual acuity
• no retinal pathology is evident and vitreous is clear
• normal vision is in contrast to Cdnk2a compound heterozygotes not carrying the floxed Pdgfr allele which show significantly compromised visual acuity
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Analysis Tools