Phenotypes associated with this allele

• Allele Symbol: Ache^tm4Pata
• Allele Name: targeted mutation 4, Palmer Taylor
• Allele ID: MGI:3842444
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ache^tm4Pata/Ache^tm4Pata	involves: 129X1/SvJ	MGI:3842462
hm2	Ache^tm4Pata/Ache^tm4Pata	involves: 129X1/SvJ * Black Swiss * C57BL/6 * FVB	MGI:3842450
cx3	Ache^tm4Pata/Ache^tm4Pata Prima1^tm1Vebe/Prima1^tm1Vebe	involves: 129X1/SvJ * C57BL/6 * DBA/2	MGI:3842461

Genotype
MGI:3842462

hm1

• Allelic Composition: Ache^tm4Pata/Ache^tm4Pata
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

infertility ( J:147425 )

• mice fail to reproduce

behavior/neurological

abnormal involuntary movement ( J:147425 )

• mice exhibit involuntary motor movement unlike wild-type mice

decreased grip strength ( J:147425 )

• decreased

abnormal posture ( J:147425 )

• mice exhibit flattened posture with limbs spread out unlike wild-type mice

hunched posture ( J:147425 )

abnormal vocalization ( J:147425 )

respiratory system

abnormal respiration ( J:147483 )

• inspiratory time is shorter than in wild-type mice

• ventilation relative to body size is mildy abnormal

decreased tidal volume ( J:147483 )

• tidal volume is increased in bambuterol-treated and untreated mice compared to similarly treated wild-type mice

increased tidal volume ( J:147483 )

• tidal volume is increased in bambuterol-treated and untreated mice compared to similarly treated wild-type mice

abnormal respiratory function ( J:147483 )

• mice exhibit increased inspiratory flow compared to in wild-type mice

increased pulmonary ventilation ( J:147483 )

• bambuterol-treated mice exhibit a rapid decrease in tidal volume compared to similarly treated wild-type mice

homeostasis/metabolism

decreased body temperature ( J:147483 )

• bambuterol-treated mice exhibit a slow decrease in body temperature compared to similarly treated wild-type mice

increased physiological sensitivity to xenobiotic ( J:147483 )

• bambuterol-treated mice exhibit a rapid decrease in tidal volume and a slow decrease in body temperature compared to similarly treated wild-type mice

growth/size/body

decreased body size ( J:147425 )

decreased body weight ( J:147425 , J:147483 )

Genotype
MGI:3842450

hm2

• Allelic Composition: Ache^tm4Pata/Ache^tm4Pata
• Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6 * FVB

behavior/neurological

decreased grip strength ( J:147855 )

• weak grip

weakness ( J:147855 )

abnormal vocalization ( J:147855 )

• mice chirp whereas wild-type mice do not

impaired exercise endurance ( J:147855 )

• mice perform poorly on a treat mill compared to wild-type mice

seizures ( J:147855 )

• mice are seizure prone compared to wild-type mice

growth/size/body

decreased body size ( J:147855 )

homeostasis/metabolism

impaired exercise endurance ( J:147855 )

• mice perform poorly on a treat mill compared to wild-type mice

muscle

muscle weakness ( J:147855 )

• mice exhibit decreased muscle strength in a wire hang, cage top hang, grip, and pole test compared to wild-type mice

nervous system

seizures ( J:147855 )

• mice are seizure prone compared to wild-type mice

reproductive system

infertility ( J:147855 )

• mice fail to raise viable pups

Genotype
MGI:3842461

cx3

• Allelic Composition: Ache^tm4Pata/Ache^tm4Pata; Prima1^tm1Vebe/Prima1^tm1Vebe
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

growth/size/body

decreased body weight ( J:147425 )

• mice exhibit decreased body weight compared to wild type mice

• however, weight loss can be reduced with a supplemental diet

homeostasis/metabolism

abnormal body temperature homeostasis ( J:147425 )

• mice exhibit postnatal thermoregulation defects