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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tacr3tm1Jasi
targeted mutation 1, Judith A Siuciak
MGI:3841488
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tacr3tm1Jasi/Tacr3tm1Jasi involves: 129P2/OlaHsd * C57BL/6 MGI:3841558


Genotype
MGI:3841558
hm1
Allelic
Composition
Tacr3tm1Jasi/Tacr3tm1Jasi
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tacr3tm1Jasi mutation (0 available); any Tacr3 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• male mice exhibit normal penile width and timing of preputial separation at P20 and timing of preputial separation at P60 (J:182547)
• male mice exhibit all stages of spermatogenesis, normal serum levels of testosterone and LH, and are fertile (J:182547)
• female mice exhibit normal average day of first estrus, ovarian weights, follicle maturation, ovulation, induced superovulation and levels of gonadotrophin, FSH and LH (J:182547)
N
• female mice exhibit normal timing of vaginal opening and first estrous (J:223528)
• at P60
• however, gross architecture is normal
• mice are acyclie or have irregular cycles
• in some mice
• female mice are sub-fertile, failing to sustain reproductive robustness
• however, the average latency to first litter is normal

endocrine/exocrine glands
N
• mice exhibit normal numbers of gonadotropin-releasing hormone neurons
• at P60
• however, gross architecture is normal

behavior/neurological
• mice require a greater number of training sessions and never reach the same level of proficiency as the wild-type mice in actively avoiding a shock by crossing into a non-shock chamber
• mice exhibit decreased latency in entering a darkened chamber they had previously been shocked in 48-72 hours earlier
• on the third day of testing in a Morris water maze, mice take significantly longer than controls to find the hidden platform

homeostasis/metabolism

growth/size/body
• on P60 in female, but not male, mice
• however, at other time points mice exhibit normal body weight
• mice weigh 7-10% more than controls; gain in weight over controls increases with age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypogonadotropic hypogonadism 11 with or without anosmia DOID:0090071 OMIM:614840
J:182547





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last database update
11/28/2017
MGI 6.11
The Jackson Laboratory