About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tacr3tm1Jasi
targeted mutation 1, Judith A Siuciak
MGI:3841488
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tacr3tm1Jasi/Tacr3tm1Jasi involves: 129P2/OlaHsd * C57BL/6 MGI:3841558


Genotype
MGI:3841558
hm1
Allelic
Composition
Tacr3tm1Jasi/Tacr3tm1Jasi
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tacr3tm1Jasi mutation (0 available); any Tacr3 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• male mice exhibit normal penile width and timing of preputial separation at P20 and timing of preputial separation at P60 (J:182547)
• male mice exhibit all stages of spermatogenesis, normal serum levels of testosterone and LH, and are fertile (J:182547)
• female mice exhibit normal average day of first estrus, ovarian weights, follicle maturation, ovulation, induced superovulation and levels of gonadotrophin, FSH and LH (J:182547)
N
• female mice exhibit normal timing of vaginal opening and first estrous (J:223528)
• at P60
• however, gross architecture is normal
• mice are acyclic or have irregular cycles
• in some mice
• female mice are sub-fertile, failing to sustain reproductive robustness
• however, the average latency to first litter is normal

endocrine/exocrine glands
N
• mice exhibit normal numbers of gonadotropin-releasing hormone neurons
• at P60
• however, gross architecture is normal

behavior/neurological
• mice require a greater number of training sessions and never reach the same level of proficiency as the wild-type mice in actively avoiding a shock by crossing into a non-shock chamber
• mice exhibit decreased latency in entering a darkened chamber they had previously been shocked in 48-72 hours earlier
• on the third day of testing in a Morris water maze, mice take significantly longer than controls to find the hidden platform

homeostasis/metabolism

growth/size/body
• on P60 in female, but not male, mice
• however, at other time points mice exhibit normal body weight
• mice weigh 7-10% more than controls; gain in weight over controls increases with age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypogonadotropic hypogonadism 11 with or without anosmia DOID:0090071 OMIM:614840
J:182547





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory