Phenotypes associated with this allele
homeostasis/metabolism
integument
|
• calcification of the fibrous capsule surrounding the muzzle vibrissae is not observed at 20 weeks of age, however, at one year of age, some calcification is present
|
growth/size/body
craniofacial
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation
(0 available);
any
Ctnnb1 mutation
(49 available)
Ctnnb1tm2Kem mutation
(1 available);
any
Ctnnb1 mutation
(49 available)
Gt(ROSA)26Sortm1(Ctnnb1)Kem mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Cdx1-cre)23Kem mutation
(1 available)
|
|
|
mortality/aging
embryo
|
• at E14.5 embryos consist of a head attached to internal organs including lung, liver and intestine while the urogenital system and mesoderm-derived tissues making up the body wall are highly underdeveloped or absent
|
|
• truncated tail bud region at E9.5
|
limbs/digits/tail
|
• truncated tail bud region at E9.5
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation
(0 available);
any
Ctnnb1 mutation
(49 available)
Ctnnb1tm2Kem mutation
(1 available);
any
Ctnnb1 mutation
(49 available)
Gt(ROSA)26Sortm1(Ctnnb1)Kem mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Cdx1-cre)23Kem mutation
(1 available)
|
|
|
mortality/aging
|
• develop until birth but do not survive
|
embryo
N |
• at E9.5 the length of tail buds are similar to controls
|
|
• abnormally folded distally at E9.5
|
renal/urinary system
reproductive system
limbs/digits/tail
|
• deformed shortened forelimb digits vertebrae at E18.5
|
|
• at E18.5 in rare cases some rudimentary upper hindlimb bones are present
|
skeleton
|
• deformed shortened fused ribs at E18.5
|
|
• deformed shortened fused vertebrae at E18.5
|
digestive/alimentary system
nervous system
|
• abnormally folded distally at E9.5
|
endocrine/exocrine glands