immune system
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• colitis results when mutant bone marrow is used to reconstitute irradiated Rag null mice
• in these bone marrow chimeras, only 7% of CD4+ T cells are regulatory T cells compared to 30% in control chimeras
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• there is a slight increase in the number of single-positive Tcr-betahi CD4+ and CD8+ mature thymocytes
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• despite increased proliferation upon activation, T cells have decreased homeostatic proliferation with only a10-20% recovery rate of wild-type in competitive bone marrow chimera assays
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• a higher percentage of CD4+T cells activated in vitro produce IFN-gamma, IL-4, IL-10 or IL-17 compared to controls
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• a higher percentage of CD8+ T cells activated in vitro produce IFN-gamma compared to controls
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• an increased percentage of splenic T cells exhibit an activated CD44hiCD62Llo or CD69+ phenotype
• there is about a 3-fold increase in activated CD4 T cells and a 5- to 10- fold increase in activated CD8 T cells
• a higher percentage of these activated T cells can produce IL-17 or IFN-gamma upon restimulation compared to activated wild-type T cells
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• mice have lymphadenopathy resulting from a rapidly proliferating CD4+ T cell population
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• mice have lymphadenopathy resulting from a rapidly proliferating CD4+ T cell population
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• mice 5-6 months of age have elevated levels of anti-nuclear antigens
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• mice 5-6 months of age have elevated levels of anti-dsDNA antigens
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digestive/alimentary system
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• colitis results when mutant bone marrow is used to reconstitute irradiated Rag null mice
• in these bone marrow chimeras, only 7% of CD4+ T cells are regulatory T cells compared to 30% in control chimeras
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hematopoietic system
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• there is a slight increase in the number of single-positive Tcr-betahi CD4+ and CD8+ mature thymocytes
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• despite increased proliferation upon activation, T cells have decreased homeostatic proliferation with only a10-20% recovery rate of wild-type in competitive bone marrow chimera assays
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• a higher percentage of CD4+T cells activated in vitro produce IFN-gamma, IL-4, IL-10 or IL-17 compared to controls
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• a higher percentage of CD8+ T cells activated in vitro produce IFN-gamma compared to controls
|
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• an increased percentage of splenic T cells exhibit an activated CD44hiCD62Llo or CD69+ phenotype
• there is about a 3-fold increase in activated CD4 T cells and a 5- to 10- fold increase in activated CD8 T cells
• a higher percentage of these activated T cells can produce IL-17 or IFN-gamma upon restimulation compared to activated wild-type T cells
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• mice have lymphadenopathy resulting from a rapidly proliferating CD4+ T cell population
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cellular
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• mice have lymphadenopathy resulting from a rapidly proliferating CD4+ T cell population
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