Phenotypes associated with this allele

• Allele Symbol: Oprm1^tm1Yxp
• Allele Name: targeted mutation 1, Ying-Xian Pan
• Allele ID: MGI:3840671
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oprm1^tm1Yxp/Oprm1^tm1Yxp	involves: 129/Sv * C57BL/6	MGI:3840672

Genotype
MGI:3840672

hm1

• Allelic Composition: Oprm1^tm1Yxp/Oprm1^tm1Yxp
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased chemically-elicited antinociception ( J:147079 )

• in radiant heat tail flick and hot plate assays the effective dose to see a response in 50% of mice (ED50) is significantly increased for heroin, morphine-6beta-glucuronide (M6G), and fentanyl

• however, the ED50 for morphine and methadone are not significantly different from controls

digestive/alimentary system

abnormal intestinal transit time ( J:147079 )

• exposure to M6G does not increase gastrointestinal transit time unlike in controls

• however, exposure to morphine increases gastrointestinal transit time in both mutants and controls