Mouse Genome Informatics
cn1
    Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo
involves: 129 * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
normal phenotype
• mice are viable and fertile


Mouse Genome Informatics
cn2
    Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo
Tg(Th-cre)1Tmd/0

involves: 129 * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• 32% reduction in levels of striatal dopamine observed in 10-11 month old mice

homeostasis/metabolism
• increased levels of norepinephrine observed in striatum in 10-11 month old mice
• 32% reduction in levels of striatal dopamine observed in 10-11 month old mice
• increased levels of 5-HT observed in prefrontal cortex in 10-11 month old mice

Mouse Models of Human Disease
OMIM IDRef(s)
Parkinson Disease 1, Autosomal Dominant; PARK1 168601 J:150777


Mouse Genome Informatics
cn3
    Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo
Tg(Th-cre)1Tmd/0

involves: 129 * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• there are significant reductions in the levels of striatal dopamine (~32%), dihydroxyphenylacetic acid (~46%) and homovanillic acid (~33%) compared to controls at 10-11 months of age
• 5-HT levels are elevated in the prefrontal cortex at 10-11 months of age compared to controls

nervous system
• there are significant reductions in the levels of striatal dopamine (~32%), dihydroxyphenylacetic acid (~46%) and homovanillic acid (~33%) compared to controls at 10-11 months of age
• norepinephrine levels in the striatum are elevated at 10-11 months of age compared to controls

Mouse Models of Human Disease
OMIM IDRef(s)
Parkinson Disease 1, Autosomal Dominant; PARK1 168601 J:150777


Mouse Genome Informatics
cn4
    Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sor+
Tg(Nes-cre)1Kln/0

involves: 129 * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
normal phenotype