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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm2(SNCA*119)Djmo
Targeted mutation 2, Darren Moore
MGI:3840596
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo involves: 129 * C57BL/6J MGI:3844719
cn2
Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo
Tg(Th-cre)1Tmd/0
involves: 129 * C57BL/6 MGI:3851906
cn3
Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo
Tg(Th-cre)1Tmd/0
involves: 129 * C57BL/6 * SJL MGI:4353816
cn4
Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sor+
Tg(Nes-cre)1Kln/0
involves: 129 * C57BL/6 * SJL MGI:4353817


Genotype
MGI:3844719
cn1
Allelic
Composition
Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(SNCA*119)Djmo mutation (1 available); any Gt(ROSA)26Sor mutation (336 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and fertile




Genotype
MGI:3851906
cn2
Allelic
Composition
Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo
Tg(Th-cre)1Tmd/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(SNCA*119)Djmo mutation (1 available); any Gt(ROSA)26Sor mutation (336 available)
Tg(Th-cre)1Tmd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 32% reduction in levels of striatal dopamine observed in 10-11 month old mice

homeostasis/metabolism
• increased levels of norepinephrine observed in striatum in 10-11 month old mice
• 32% reduction in levels of striatal dopamine observed in 10-11 month old mice
• increased levels of 5-HT observed in prefrontal cortex in 10-11 month old mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Parkinson Disease 1, Autosomal Dominant; PARK1 168601 J:150777




Genotype
MGI:4353816
cn3
Allelic
Composition
Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo
Tg(Th-cre)1Tmd/0
Genetic
Background
involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(SNCA*119)Djmo mutation (1 available); any Gt(ROSA)26Sor mutation (336 available)
Tg(Th-cre)1Tmd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• there are significant reductions in the levels of striatal dopamine (~32%), dihydroxyphenylacetic acid (~46%) and homovanillic acid (~33%) compared to controls at 10-11 months of age
• 5-HT levels are elevated in the prefrontal cortex at 10-11 months of age compared to controls

nervous system
• there are significant reductions in the levels of striatal dopamine (~32%), dihydroxyphenylacetic acid (~46%) and homovanillic acid (~33%) compared to controls at 10-11 months of age
• norepinephrine levels in the striatum are elevated at 10-11 months of age compared to controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Parkinson Disease 1, Autosomal Dominant; PARK1 168601 J:150777




Genotype
MGI:4353817
cn4
Allelic
Composition
Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sor+
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(SNCA*119)Djmo mutation (1 available); any Gt(ROSA)26Sor mutation (336 available)
Tg(Nes-cre)1Kln mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype





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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory