Phenotypes associated with this allele

• Allele Symbol: Cd63^tm1Psa
• Allele Name: targeted mutation 1, Paul Saftig
• Allele ID: MGI:3840228
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd63^tm1Psa/Cd63^tm1Psa	involves: 129P2/OlaHsd * C57BL/6J	MGI:3840230

Genotype
MGI:3840230

hm1

• Allelic Composition: Cd63^tm1Psa/Cd63^tm1Psa
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal urine homeostasis ( J:145741 )

• the urinary concentrations of the main electrolytes, phosphate, and urea were reduced by half

• the overall 24-h excretions were not altered

decreased urine osmolality ( J:145741 )

abnormal kidney collecting duct principal cell morphology ( J:145741 )

• accumulation of abnormal cytoplasmic inclusions with a concentrically lamellar pattern in the principal cells of the collecting duct

polyuria ( J:145741 )

• a significant increase in urine production, paralleled by a respective increase in water uptake

behavior/neurological

polydipsia ( J:145741 )

• a significant increase in urine production, paralleled by a respective increase in water uptake

homeostasis/metabolism

abnormal fluid regulation ( J:145741 )

• a significantly higher water content in fecal dropping due to disturbance in water homeostasis

abnormal urine homeostasis ( J:145741 )

• the urinary concentrations of the main electrolytes, phosphate, and urea were reduced by half

• the overall 24-h excretions were not altered

decreased urine osmolality ( J:145741 )

digestive/alimentary system

abnormal feces composition ( J:145741 )

• significantly increased fecal water content