Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1.1Erns mutation
(0 available);
any
Kmt2a mutation
(135 available)
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hematopoietic system
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• retroviral cre-treated myelo-erythroid progenitor cells exhibit reduced proliferation and a 2.6-fold reduction in re-entry into the cell cycle following serum and cytokine starvation compared to wild-type cells
• however, the composition of cell populations produced is normal
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• bone marrow cells treated with retroviral cre produce 2-fold fewer myeloid colony forming units compared to wild-type cells
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• bone marrow cells treated with retroviral cre produce 2-fold fewer erythroid colony forming units compared to wild-type cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation
(11 available);
any
Cd19 mutation
(56 available)
Kmt2atm1.1Erns mutation
(0 available);
any
Kmt2a mutation
(135 available)
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immune system
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N |
• mice exhibit normally differentiating T, B, and myeloid cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1.1Erns mutation
(0 available);
any
Kmt2a mutation
(135 available)
Lyz2tm1(cre)Ifo mutation
(14 available);
any
Lyz2 mutation
(41 available)
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immune system
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N |
• mice exhibit normally differentiating T, B, and myeloid cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1.1Erns mutation
(0 available);
any
Kmt2a mutation
(135 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation
(2 available)
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nervous system
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• subventricular neural stem cells treated in culture with adenoviral cre exhibit decreased differentiation compared to wild-type cells
• under differentiation condition, cultured subventricular zone cells treated with adenovirus cre produce 2-fold more oligodendrocytes and 50% more astrocytes than similarly treated wild-type cells
• however, proliferation and apoptosis rates are normal
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• under differentiation condition, cultured subventricular zone cells treated with adenovirus cre produce 3-fold fewer Tuj1+ (marking neuron precursor cells) compared similarly treated wild-type cells
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cellular
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• subventricular neural stem cells treated in culture with adenoviral cre exhibit decreased differentiation compared to wild-type cells
• under differentiation condition, cultured subventricular zone cells treated with adenovirus cre produce 2-fold more oligodendrocytes and 50% more astrocytes than similarly treated wild-type cells
• however, proliferation and apoptosis rates are normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1.1Erns mutation
(0 available);
any
Kmt2a mutation
(135 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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mortality/aging
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• mice die within days of pIpC treatment unlike similarly treated wild-type mice
• however, pIpC-treated mice injected with wild-type bone marrow survive
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hematopoietic system
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• myelo-erythroid progenitor cells from pIpC-treated mice exhibit reduced proliferation and a 2.6-fold reduction in re-entry into the cell cycle following serum and cytokine starvation compared to wild-type cells
• however, the composition of cell populations produced is normal
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• 11 days after pIpC, treatment common myeloid progenitors, granulocyte-progenitors, and megakaryocyte-erythrocyte progenitors are decreased 1.4- to 4-fold compared to in wild-type mice
• cultured bone marrow cells of pIpC-treated mice exhibit a 2- to 5-fold decrease in myeloid colonies compared to wild-type cells
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• pIpC-treated mice exhibit bone marrow cytopenia unlike in wild-type mice
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• 11 days after pIpC treatment, lymphocyte progenitor cells are decreased 1.4- to 4-fold compared to in wild-type mice
• cultured bone marrow cells of pIpC-treated mice exhibit a 2- to 5-fold decrease in lymphoid colonies compared to wild-type cells
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• 11 days after pIpC, treatment common myeloid progenitors, granulocyte-progenitors, and megakaryocyte-erythrocyte progenitors are decreased 1.4- to 4-fold compared to in wild-type mice
• cultured bone marrow cells of pIpC-treated mice exhibit a 2- to 5-fold decrease in erythroid colonies compared to wild-type cells
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• pIpC-treated mice exhibit a loss of hematopoietic stem cell (HSC) renewal followed by an increase in HSC proliferation and subsequent depletion of these cells unlike in wild-type mice
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• pIpC-treated mice exhibit a cell-intrinsic loss of hematopoietic stem cell-enriched KSL populations and loss of hematopoietic stem cell activity unlike similarly treated wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1.1Erns mutation
(0 available);
any
Kmt2a mutation
(135 available)
Tg(Lck-cre)1Cwi mutation
(3 available)
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immune system
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N |
• mice exhibit normally differentiating T, B, and myeloid cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1.1Erns mutation
(0 available);
any
Kmt2a mutation
(135 available)
Tg(GFAP-cre)25Mes mutation
(2 available)
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mortality/aging
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• mice die between P25 and P30
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nervous system
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• cultured subventricular cells produce fewer neuronal cells while remaining gliogenic unlike wild-type cells
• however, cultured subventricular cells exhibit normal proliferation and apoptosis
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• neuroblast chain migration in mice and from subventricular zone explants is severely disorganized, and migration is reduced 40% compared to wild-type cells
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• all regions of the brain that undergo postnatal neurogenesis including the cerebellar granule cell layer, hippocampal dentate gyrus, and olfactory bulb are reduced in size compared to in wild-type mice
• however, the ependymal layer and oligodendrocytes develop normally
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• reduced in size with reduced neurons
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• the expanded subventricular zone contains 3- to 4-fold fewer proliferating neuroblasts compared to in wild-type mice
• after P7, neuroblasts accumulate in the subventricular zone due to impaired migration unlike in wild-type mice
• the subventricular zone contains more cells positive for an astrocyte-specific marker than in wild-type mice
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• the subventricular zone and other brain regions contains more cells positive for an astrocyte-specific marker than in wild-type mice
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• the subventricular zone contains 3- to 4-fold fewer proliferating neuroblasts compared to in wild-type mice
• under differentiation condition, cultured subventricular zone cells produce more than 20-fold fewer Tuj1+ (marking neuron precursor cells) compared similarly treated wild-type cells
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behavior/neurological
growth/size/body
cellular
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• cultured subventricular cells produce fewer neuronal cells while remaining gliogenic unlike wild-type cells
• however, cultured subventricular cells exhibit normal proliferation and apoptosis
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• neuroblast chain migration in mice and from subventricular zone explants is severely disorganized, and migration is reduced 40% compared to wild-type cells
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Analysis Tools