cardiovascular system

cardiovascular system phenotype ( J:146091 )

N	• unlike human patients with familial hypertrophic cardiomyopathy, mice fail to exhibit cardiac hypertrophy (J:146091)

cardiac fibrosis ( J:146091 )

• at 17 months of age

abnormal myocardial fiber physiology ( J:146091 )

• skinned muscle fibers exhibit increased delta pCa50 values of ATPase and force-pCa relationship compared to in wild-type fibers

• maximal ATPase in skinned muscle fibers is reduced 22% compared to in wild-type cells

• maximal force in skinned muscle fibers is reduced 32% compared to in wild-type cells

• papillary muscle fibers exhibit slower myosin cross-bridge dissociation and normalized force compared to wild-type mice

Mouse Models of Human Disease		OMIM ID	Ref(s)
Cardiomyopathy, Familial Hypertrophic, 8; CMH8		608751	J:146091