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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6-MYL2*D166V)1Dsc
transgene insertion 1, Danuta Szczesna-Cordary
MGI:3838172
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Myh6-MYL2*D166V)1Dsc/0 involves: C57BL/6 * SJL MGI:3838173


Genotype
MGI:3838173
tg1
Allelic
Composition
Tg(Myh6-MYL2*D166V)1Dsc/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• unlike human patients with familial hypertrophic cardiomyopathy, mice fail to exhibit cardiac hypertrophy
• at 17 months of age
• skinned muscle fibers exhibit increased delta pCa50 values of ATPase and force-pCa relationship compared to in wild-type fibers
• maximal ATPase in skinned muscle fibers is reduced 22% compared to in wild-type cells
• maximal force in skinned muscle fibers is reduced 32% compared to in wild-type cells
• papillary muscle fibers exhibit slower myosin cross-bridge dissociation and normalized force compared to wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Cardiomyopathy, Familial Hypertrophic, 10; CMH10 608758 J:146091





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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory