Mouse Genome Informatics
hm1
    Pink1tm1Zhzh/Pink1tm1Zhzh
involves: 129P2/OlaHsd * C57BL/6J
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed


Mouse Genome Informatics
cx2
    Pink1tm1Zhzh/Pink1tm1Zhzh
Slc6a3tm4.1(tTA)Xz/?
Tg(tetO-SNCA*A53T)E2Cai/?

involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• 51% reduction of mitochondrial mass at 3 weeks of age

nervous system
• "mitochondrial inclusions are observed in in dopaminergic neurons beginning at 3 weeks of age
• inclusions average 4.2 um in diameter and are labeled by mitochondrial markers (COX1, SOD2)
• number of inclusions is approximately 1.4 inclusions per dopaminergic neuron