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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pink1tm1Zhzh
targeted mutation 1, Zhuohua Zhang
MGI:3837552
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pink1tm1Zhzh/Pink1tm1Zhzh involves: 129P2/OlaHsd * C57BL/6J MGI:3837554
cx2
Pink1tm1Zhzh/Pink1tm1Zhzh
Slc6a3tm4.1(tTA)Xz/?
Tg(tetO-SNCA*A53T)E2Cai/?
involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 MGI:5619815


Genotype
MGI:3837554
hm1
Allelic
Composition
Pink1tm1Zhzh/Pink1tm1Zhzh
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pink1tm1Zhzh mutation (0 available); any Pink1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed




Genotype
MGI:5619815
cx2
Allelic
Composition
Pink1tm1Zhzh/Pink1tm1Zhzh
Slc6a3tm4.1(tTA)Xz/?
Tg(tetO-SNCA*A53T)E2Cai/?
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pink1tm1Zhzh mutation (0 available); any Pink1 mutation (20 available)
Slc6a3tm4.1(tTA)Xz mutation (1 available); any Slc6a3 mutation (32 available)
Tg(tetO-SNCA*A53T)E2Cai mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• 51% reduction of mitochondrial mass at 3 weeks of age

nervous system
• "mitochondrial inclusions are observed in in dopaminergic neurons beginning at 3 weeks of age
• inclusions average 4.2 um in diameter and are labeled by mitochondrial markers (COX1, SOD2)
• number of inclusions is approximately 1.4 inclusions per dopaminergic neuron





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory