All Phenotypes Thrb<tm1Mkni> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Thrb^tm1Mkni
targeted mutation 1, Marlies Knipper
MGI:3836780

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Thrb^tm1Df/Thrb^tm1Mkni Tg(Pres-cre)1Jnz/0	involves: 129S1/Sv * C57BL/6J * FVB/NJ	MGI:3836781
cn2	Thrb^tm1Mkni/Thrb^tm1Mkni Hprt1^{tm1(TG-cre)1Sasr}/Y	involves: 129/Sv * C57BL/6	MGI:5576933
cn3	Thrb^tm1Mkni/Thrb⁺ Hprt1^{tm1(TG-cre)1Sasr}/Y	involves: 129/Sv * C57BL/6	MGI:5576934

Allelic Composition	Thrb^tm1Df/Thrb^tm1Mkni Tg(Pres-cre)1Jnz/0
Genetic Background	involves: 129S1/Sv * C57BL/6J * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pres-cre)1Jnz mutation (0 available)
Thrb^tm1Df mutation (1 available); any Thrb mutation (39 available)
Thrb^tm1Mkni mutation (0 available); any Thrb mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal cochlear inner hair cell physiology ( J:145941 )

• voltage activated K+ currents are absent from inner hair cells

increased or absent threshold for auditory brainstem response ( J:145941 )

• significant increase in ABR thresholds at frequencies less than 8 kHz

nervous system

abnormal cochlear inner hair cell physiology ( J:145941 )

• voltage activated K+ currents are absent from inner hair cells

Allelic Composition	Thrb^tm1Mkni/Thrb^tm1Mkni Hprt1^{tm1(TG-cre)1Sasr}/Y
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm1(TG-cre)1Sasr} mutation (0 available); any Hprt1 mutation (1273 available)
Thrb^tm1Mkni mutation (0 available); any Thrb mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased thyroid gland weight ( J:208718 )

• significantly reduced at 2 months, compared to controls

growth/size/body

growth/size/body region phenotype ( J:208718 )

N	• body weight is not different from wild-type in 2-month old males

homeostasis/metabolism

decreased circulating thyroid-stimulating hormone level ( J:208718 )

• serum levels are decreased by 20%

abnormal thyroid hormone level ( J:208718 )

• thyroid free T3 levels are not different from controls, but free rT3 levels are significantly elevated in the thyroid increased in 20 month old males; T4/rT3 ratios are elevated

increased circulating levels of thyroid hormone ( J:208718 )

• T3 levels are unchanged, but rT3 (reverse triiodothyronine) levels are significantly increased

increased circulating thyroxine level ( J:208718 )

• serum levels are significantly increased at 2 months

increased thyroxine level ( J:208718 )

• thyroid free T4 and thyroglobulin-bound T4 levels in the thyroid gland are significantly increased in 20 month old males; T4/T3 ratios are elevated

Allelic Composition	Thrb^tm1Mkni/Thrb⁺ Hprt1^{tm1(TG-cre)1Sasr}/Y
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased thyroid gland weight ( J:208718 )

• significantly reduced at 2 months, compared to controls

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