Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Achn mutation
(1 available);
any
Blnk mutation
(76 available)
Btktm1Wk mutation
(1 available);
any
Btk mutation
(22 available)
Tg(IGH-Btk)1Witt mutation
(0 available)
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immune system
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• impairment in the early and late phases of Ca2+ mobilization following BCR stimulation
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• fail to proliferate after BCR cross linking
• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased
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hematopoietic system
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• impairment in the early and late phases of Ca2+ mobilization following BCR stimulation
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• fail to proliferate after BCR cross linking
• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased
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cellular
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• fail to proliferate after BCR cross linking
• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btktm1Wk mutation
(1 available);
any
Btk mutation
(22 available)
Tg(IGH-Btk)1Witt mutation
(0 available)
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immune system
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• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased
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hematopoietic system
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• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased
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cellular
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• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btkxid mutation
(3 available);
any
Btk mutation
(22 available)
Tg(IGH-Btk)1Witt mutation
(0 available)
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immune system
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• less sensitive to anti-IgM induced proliferation compared to wild-type controls
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• the percentage of peritoneal B220+CD5+ cells is decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene
• however, the frequency and number of splenic B cells are similar to wild-type controls
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• basal serum IgG3 levels are decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene
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• serum levels of IgM following TNP-Ficoll treatment are reduced compared to wild-type controls
• basal serum IgM levels are decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene
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hematopoietic system
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• less sensitive to anti-IgM induced proliferation compared to wild-type controls
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• the percentage of peritoneal B220+CD5+ cells is decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene
• however, the frequency and number of splenic B cells are similar to wild-type controls
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• basal serum IgG3 levels are decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene
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• serum levels of IgM following TNP-Ficoll treatment are reduced compared to wild-type controls
• basal serum IgM levels are decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene
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cellular
|
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• less sensitive to anti-IgM induced proliferation compared to wild-type controls
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btkxid mutation
(3 available);
any
Btk mutation
(22 available)
Tg(IGH-Btk)1Witt mutation
(0 available)
|
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immune system
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• less sensitive to anti-IgM induced proliferation compared to wild-type controls but more responsive than mutant mice hemizygous for the transgene
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• in most mice the percentage of peritoneal B220+CD5+ cells is decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene
• however, some mice had frequencies of B1 cells near the normal range
• the frequency and number of splenic B cells are similar to wild-type controls
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• basal serum IgG3 levels are decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene
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• serum levels of IgM following TNP-Ficoll treatment are reduced compared to wild-type controls
• basal serum IgM levels are decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene
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hematopoietic system
|
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• less sensitive to anti-IgM induced proliferation compared to wild-type controls but more responsive than mutant mice hemizygous for the transgene
|
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• in most mice the percentage of peritoneal B220+CD5+ cells is decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene
• however, some mice had frequencies of B1 cells near the normal range
• the frequency and number of splenic B cells are similar to wild-type controls
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• basal serum IgG3 levels are decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene
|
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• serum levels of IgM following TNP-Ficoll treatment are reduced compared to wild-type controls
• basal serum IgM levels are decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene
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cellular
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• less sensitive to anti-IgM induced proliferation compared to wild-type controls but more responsive than mutant mice hemizygous for the transgene
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Analysis Tools