Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plvaptm1.1Rvst mutation
(1 available);
any
Plvap mutation
(47 available)
Tg(Cdh5-cre)1Spe mutation
(2 available)
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mortality/aging
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• Background Sensitivity: display 100% lethality by P2 on a congenic C57BL/6 background unlike mice on a mixed background where about 20-30% of mice survive to 6-7 months of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm3Spe mutation
(0 available);
any
Runx1 mutation
(35 available)
Tg(Cdh5-cre)1Spe mutation
(2 available)
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mortality/aging
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• 65% of embryos die between E12.5 and E15.5
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hematopoietic system
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• 10% of E12.5 embryos have a pale liver due to anemia
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• hematopoietic stem cell first derive as clusters of Kithigh cells from the endothelium of dorsal aorta and vitelline and umbilical arteries of E10.5 conceptus
• these clusters are absent in mutant E10.5 conceptus and there is a 90-fold decrease in the Kithigh cells
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• there is about a 8-fold decrease in CFUs from the yolk sac, vitelline and umbilical arteries, placenta and fetal liver
• over 99% of the CFUs that do develop in culture have one functional Runx1 allele
• decreased hematopoietic stem cell numbers are reflected in poor engraftment of mutant bone marrow cells into irradiated recipients
• CFUs cultured from bone marrow of transplant recipients are much reduced compared to controls and over 99% also have one functional Runx1 allele
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cardiovascular system
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• 10% of E12.5 embryos have hemorrhaging within the central nervous system
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liver/biliary system
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• 10% of E12.5 embryos have a pale liver due to anemia
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plvaptm1.1Rvst mutation
(1 available);
any
Plvap mutation
(47 available)
Tg(Cdh5-cre)1Spe mutation
(2 available)
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mortality/aging
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• Background Sensitivity: display 100% lethality by P2 on a congenic C57BL/6 background unlike mice on a mixed background where about 20-30% of mice survive to 6-7 months of age
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cardiovascular system
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• lack diaphragms in endothelial fenestrae, transendothelial channels, and caveolae in pancreas, intestine, kidney, lung and adrenals
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• leakage of Evans Blue dye is dramatically increased in organs with fenestrated endothelial cells
• leakage of Evans Blue dye is highest in the intestine
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homeostasis/metabolism
growth/size/body
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• due to accumulation of ascites
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adipose tissue
endocrine/exocrine glands
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Best3tm1.1Zhoj mutation
(0 available);
any
Best3 mutation
(37 available)
Tg(Cdh5-cre)1Spe mutation
(2 available)
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cardiovascular system
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N |
• no effect on development of aortic dissections or change in blood pressure
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Analysis Tools
