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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Cdh5-cre)1Spe
transgene insertion 1, Nancy A Speck
MGI:3836418
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Plvaptm1.1Rvst/Plvaptm1.1Rvst
Tg(Cdh5-cre)1Spe/0
B6.Cg-Plvaptm1.1Rvst Tg(Cdh5-cre)1Spe MGI:5473520
cn2
Runx1tm3Spe/Runx1tm3Spe
Tg(Cdh5-cre)1Spe/0
involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6 MGI:3836436
cn3
Plvaptm1.1Rvst/Plvaptm1.1Rvst
Tg(Cdh5-cre)1Spe/0
involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6 * C57BL/6J MGI:5473519


Genotype
MGI:5473520
cn1
Allelic
Composition
Plvaptm1.1Rvst/Plvaptm1.1Rvst
Tg(Cdh5-cre)1Spe/0
Genetic
Background
B6.Cg-Plvaptm1.1Rvst Tg(Cdh5-cre)1Spe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plvaptm1.1Rvst mutation (1 available); any Plvap mutation (49 available)
Tg(Cdh5-cre)1Spe mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: display 100% lethality by P2 on a congenic C57BL/6 background unlike mice on a mixed background where about 20-30% of mice survive to 6-7 months of age




Genotype
MGI:3836436
cn2
Allelic
Composition
Runx1tm3Spe/Runx1tm3Spe
Tg(Cdh5-cre)1Spe/0
Genetic
Background
involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm3Spe mutation (0 available); any Runx1 mutation (12 available)
Tg(Cdh5-cre)1Spe mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

hematopoietic system
• 10% of E12.5 embryos have a pale liver due to anemia
• hematopoietic stem cell first derive as clusters of Kithigh cells from the endothelium of dorsal aorta and vitelline and umbilical arteries of E10.5 conceptus
• these clusters are absent in mutant E10.5 conceptus and there is a 90-fold decrease in the Kithigh cells
• there is about a 8-fold decrease in CFUs from the yolk sac, vitelline and umbilical arteries, placenta and fetal liver
• over 99% of the CFUs that do develop in culture have one functional Runx1 allele
• decreased hematopoietic stem cell numbers are reflected in poor engraftment of mutant bone marrow cells into irradiated recipients
• CFUs cultured from bone marrow of transplant recipients are much reduced compared to controls and over 99% also have one functional Runx1 allele

cardiovascular system
• 10% of E12.5 embryos have hemorrhaging within the central nervous system

liver/biliary system
• 10% of E12.5 embryos have a pale liver due to anemia




Genotype
MGI:5473519
cn3
Allelic
Composition
Plvaptm1.1Rvst/Plvaptm1.1Rvst
Tg(Cdh5-cre)1Spe/0
Genetic
Background
involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plvaptm1.1Rvst mutation (1 available); any Plvap mutation (49 available)
Tg(Cdh5-cre)1Spe mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: display 100% lethality by P2 on a congenic C57BL/6 background unlike mice on a mixed background where about 20-30% of mice survive to 6-7 months of age

cardiovascular system
• lack diaphragms in endothelial fenestrae, transendothelial channels, and caveolae in pancreas, intestine, kidney, lung and adrenals
• leakage of Evans Blue dye is dramatically increased in organs with fenestrated endothelial cells
• leakage of Evans Blue dye is highest in the intestine

homeostasis/metabolism
• significantly decreased at 4 weeks of age and does not vary much with time
• moderate increase at 4 weeks of age that does not vary much with time
• plasma levels are increased 30- to 100-fold from 4 to 8 weeks of age
• fluid contains albumin and beta globins at similar levels to blood plasma but sharply reduced alpha fractions

growth/size/body
• due to accumulation of ascites

adipose tissue

endocrine/exocrine glands





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory