Phenotypes associated with this allele

• Allele Symbol: Vtcn1^tm1Lpc
• Allele Name: targeted mutation 1, Lieping Chen
• Allele ID: MGI:3836401
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vtcn1^tm1Lpc/Vtcn1^tm1Lpc	B6.129S-Vtcn1^tm1Lpc	MGI:3836412
cx2	Rag1^tm1Mom/Rag1^tm1Mom Vtcn1^tm1Lpc/Vtcn1^tm1Lpc	involves: 129S/SvEvBrd * 129S7/SvEvBrd * C57BL/6	MGI:3836413

Genotype
MGI:3836412

hm1

• Allelic Composition: Vtcn1^tm1Lpc/Vtcn1^tm1Lpc
• Genetic Background: B6.129S-Vtcn1^tm1Lpc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:145712 )

• 40% of Listeria-infected mice surviving beyond the end of the study unlike similarly treated wild-type mice that die by day 9 post-infection

immune system

abnormal myelopoiesis ( J:145712 )

• proliferation of Gr1+CD11b+ neutrophil progenitors is increased compared to in wild-type mice

increased neutrophil cell number ( J:145712 )

• following infection with Listeria or treatment with LPS

decreased susceptibility to bacterial infection ( J:145712 )

• mice infected with Listeria exhibit increased survival, neutrophil numbers, and bacterial clearance compared to wild-type mice

• however, depletion of Gr-1+ neutrophils increases bacterial load in Listeria-infected mice

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:145712 )

• 40% of Listeria-infected mice surviving beyond the end of the study unlike similarly treated wild-type mice that die by day 9 post-infection

hematopoietic system

abnormal myelopoiesis ( J:145712 )

• proliferation of Gr1+CD11b+ neutrophil progenitors is increased compared to in wild-type mice

increased neutrophil cell number ( J:145712 )

• following infection with Listeria or treatment with LPS

Genotype
MGI:3836413

cx2

• Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom; Vtcn1^tm1Lpc/Vtcn1^tm1Lpc
• Genetic Background: involves: 129S/SvEvBrd * 129S7/SvEvBrd * C57BL/6

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:145712 )

• Listeria-infected mice die by day 15 post-infection compared to Rag1^tm1Mom homozygotes that die at day 4 post-infection

immune system

abnormal neutrophil differentiation ( J:145712 )

• proliferation of Gr1+CD11b+ neutrophil progenitors is increased compared to in Rag1^tm1Mom homozygotes

increased spleen weight ( J:145712 )

increased neutrophil cell number ( J:145712 )

• compared to in Rag1^tm1Mom homozygotes

decreased susceptibility to bacterial infection ( J:145712 )

• mice infected with Listeria exhibit increased neutrophil numbers and increased bacterial clearance compared to similarly treated Rag1^tm1Mom homozygotes

• however, depletion of Gr-1+ neutrophils increases bacterial load in Listeria-infected mice

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:145712 )

• Listeria-infected mice die by day 15 post-infection compared to Rag1^tm1Mom homozygotes that die at day 4 post-infection

hematopoietic system

abnormal neutrophil differentiation ( J:145712 )

• proliferation of Gr1+CD11b+ neutrophil progenitors is increased compared to in Rag1^tm1Mom homozygotes

increased spleen weight ( J:145712 )

increased neutrophil cell number ( J:145712 )

• compared to in Rag1^tm1Mom homozygotes

cellular

abnormal neutrophil differentiation ( J:145712 )

• proliferation of Gr1+CD11b+ neutrophil progenitors is increased compared to in Rag1^tm1Mom homozygotes

growth/size/body

increased spleen weight ( J:145712 )