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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Crtamtm1Achn
targeted mutation 1, Andrew C Chan
MGI:3834613
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Crtamtm1Achn/Crtamtm1Achn involves: 129 * C57BL/6 MGI:3834614


Genotype
MGI:3834614
hm1
Allelic
Composition
Crtamtm1Achn/Crtamtm1Achn
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crtamtm1Achn mutation (0 available); any Crtam mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• CD4+ T cell numbers increase with age so that by 9 months the number is more than two-thirds higher than in wild-type controls in both blood and lymph nodes
• CD8+ T cell numbers increase with age so that by 9 months they are more than two-thirds higher than in wild-type controls in both blood and lymph nodes
• Th17 T cells produce less IL-17 and IL-22 than controls when stimulated
• Th1 T cells produce less IFN-gamma than controls when activated
• 14 hours after activation, T cells fail to efficiently polarize Talin, CD44, and CD3 in the manner that wild-type T cells do
• both CD4+ and CD8+ T cells proliferate at a faster rate in vitro and in vivo
• there is a 5-fold decrease in IFN-gamma production by Th1 differentiated T cells with both primary and secondary TCR stimulations
• nave and memory/effector CD8+ T cells also produce less IFN-gamma when stimulated
• Th17 differentiated T cells produce less IL-22 than controls
• Th17 differentiated T cells produce less IL-17 than controls
• there is a one log unit increase in bacterial burden in the colon 7 days after Citrobacter rodentium infection
• there is two log unit increase in bacterial burden in the spleen 7 and 14 days after C. rodentium infection

hematopoietic system
• CD4+ T cell numbers increase with age so that by 9 months the number is more than two-thirds higher than in wild-type controls in both blood and lymph nodes
• CD8+ T cell numbers increase with age so that by 9 months they are more than two-thirds higher than in wild-type controls in both blood and lymph nodes
• Th17 T cells produce less IL-17 and IL-22 than controls when stimulated
• Th1 T cells produce less IFN-gamma than controls when activated
• 14 hours after activation, T cells fail to efficiently polarize Talin, CD44, and CD3 in the manner that wild-type T cells do
• both CD4+ and CD8+ T cells proliferate at a faster rate in vitro and in vivo

cellular
• both CD4+ and CD8+ T cells proliferate at a faster rate in vitro and in vivo





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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory