|
Allele Symbol Allele Name Allele ID |
Nrarptm1Vlcg targeted mutation 1, Velocigene MGI:3833551 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• retinal capillaries are less resistant to oxygen-induced vaso-obliteration compared with wild-type capillaries
|
|
• retinal capillaries are less resistant to oxygen-induced vaso-obliteration compared with wild-type capillaries
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• at P7, radial expansion of the retinal vascular plexus from the optic nerve head to the periphery is impaired
• vessel density is decreased compared to in wild-type retina
• however, retinal vascular angiogenesis is partially resolved by P10, and only mild patterning defects are present at P14
• retinal vasculature is narrow at branch points, unstable and poorly lumenized with slender sprouts compared to in wild-type retina
• the continuous junctions that decorate the capillary plexus in the retina are fragmented compared to in wild-type retinas
• proliferation of endothelial cells in the retina is decreased compared to in wild-type retina
• however, pericyte recruitment is normal
|
|
• more vessel regression is observed in the retina than in wild-type mice
• constitutive activation of Ctnnb1 of inhibition of Notch signaling by DAPT treatment fails to rescue vessel regression
|
|
• at P7, radial expansion of the retinal vascular plexus from the optic nerve head to the periphery is impaired
• however, retinal vascular angiogenesis is partially resolved by P10, and only mild patterning defects are present at P14
|
|
• proliferation of endothelial cells in the retina is decreased compared to in wild-type retina
|
|
• at P7, radial expansion of the retinal vascular plexus from the optic nerve head to the periphery is impaired
• vessel density is decreased compared to in wild-type retina
• however, retinal vascular angiogenesis is partially resolved by P10, and only mild patterning defects are present at P14
• retinal vasculature is narrow at branch points, unstable and poorly lumenized with slender sprouts compared to in wild-type retina
• the continuous junctions that decorate the capillary plexus in the retina are fragmented compared to in wild-type retinas
• proliferation of endothelial cells in the retina is decreased compared to in wild-type retina
• however, pericyte recruitment is normal
|
|
• more vessel regression is observed in the retina than in wild-type mice
• constitutive activation of Ctnnb1 of inhibition of Notch signaling by DAPT treatment fails to rescue vessel regression
|
|
• proliferation of endothelial cells in the retina is decreased compared to in wild-type retina
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• at P7, radial expansion of the retinal vascular plexus from the optic nerve head to the periphery is impaired
• however, retinal vascular angiogenesis is partially resolved by P10, and only mild patterning defects are present at P14
• vessel density is decreased compared to in wild-type retina
• retinal vasculature exhibits slender sprouts compared to in wild-type retina
|
|
• more vessel regression is observed in the retina than in wild-type mice
|
|
• at P7, radial expansion of the retinal vascular plexus from the optic nerve head to the periphery is impaired
• however, retinal vascular angiogenesis is partially resolved by P10, and only mild patterning defects are present at P14
|
|
• at P7, radial expansion of the retinal vascular plexus from the optic nerve head to the periphery is impaired
• however, retinal vascular angiogenesis is partially resolved by P10, and only mild patterning defects are present at P14
• vessel density is decreased compared to in wild-type retina
• retinal vasculature exhibits slender sprouts compared to in wild-type retina
|
|
• more vessel regression is observed in the retina than in wild-type mice
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/09/2024 MGI 6.23 |
|
|
|
||
Analysis Tools