Analysis Tools
behavior/neurological
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• in contextual fear-conditioning test, mice show less freezing behavior in the 30 min and 24 hours after training
• mice treated with clonazepam show rescue of impaired context-dependent fear conditioning
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• in the elevated-plus maze, mice enter the open arms less frequently and spend less time in the open arms
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• mice spend less time in the center of the open field
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• mice travel more in the open field
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• in the open field social interaction test, mice spend less time interacting with the caged stranger mouse
• in the three-chamber social preference test, mice show no preference for the stranger mouse over an inanimate object
• mice treated with clonazepam, a positive allosteric modulator of the GABA-A receptor, show rescue of impaired social behaviors in the open arena and three-chamber test and this effect is reversed after 1 week clearing period
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nervous system
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• frequency of spontaneous EPSCs in hippocampal CA1 and prefrontal cortex slices is increased
• treatment with clonazepam leads to a decrease in frequency of spontaneous EPSCs, without change in amplitude
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• frequency of spontaneous IPSCs in hippocampal CA1 and prefrontal cortex slices is reduced
• treatment with clonazepam increases spontaneous IPSC amplitude in the hippocampal CA1 region, but not frequency
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autism spectrum disorder | DOID:0060041 | J:188126 | ||
| Dravet syndrome | DOID:0080422 |
OMIM:607208 |
J:188126 | |
