Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
enu164 mutation
(0 available);
any
enu164 mutation
(0 available)
Tg(Thy1-MAPT*K369I)K3Gotz mutation
(1 available)
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behavior/neurological
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• at 6 weeks, some mice exhibit improved motor impairments (reduced severity of abnormal gait, clasping and tremor) compared with Tg(Thy1-MAPT*K369I)K3Gotz mice
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• improved at 6 weeks compared with Tg(Thy1-MAPT*K369I)K3Gotz mice
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• improved at 6 weeks compared with Tg(Thy1-MAPT*K369I)K3Gotz mice
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• improved at 6 weeks compared with Tg(Thy1-MAPT*K369I)K3Gotz mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
enu67 mutation
(0 available);
any
enu67 mutation
(0 available)
Tg(Thy1-MAPT*K369I)K3Gotz mutation
(1 available)
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growth/size/body
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• compared with wild-type and Tg(Thy1-MAPT*K369I)K3Gotz mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-MAPT*K369I)K3Gotz mutation
(1 available)
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behavior/neurological
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• mice exhibit a strong cataleptic response to lower doses of the dopamine antagonist haloperidol compared to wild-type mice
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• at 4 months, mice exhibit a lack of preference for a novel object compared to wild-type mice indicating impaired working memory
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• mice exhibit postural instability as indicated by repeated slipping while crossing a narrow beam unlike wild-type mice
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• beginning at 4 weeks of age and becoming severe by 8 weeks of age
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• mice exhibit reduced motor coordination on a challenging beam compared to wild-type mice
• mice exhibit postural instability as indicated by repeated slipping while crossing a narrow beam unlike wild-type mice
• motor coordination of old mice is not improved with L-dopa treatment
• however, motor coordination of young mice is improved with L-dopa treatment
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• by 38% at 4 weeks of age
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• at 4 weeks of age, mice exhibit repeated and prolonged resting phases in an open field compared to in wild-type mice
• at 2 months, mice exhibit reduced locomotor activity and rearing in an open field compared to wild-type mice
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nervous system
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• despite muscular atrophy, no overt neurodegeneration is detected
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• at 5 months, mice develop Bielschowsky silver+ intraneuronal inclusions unlike in wild-type mice
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• age-dependent beginning at 12 months of age in the substantia nigra
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• at 2 months, a few axonal swellings are detected unlike in wild-type mice
• spheroids are detected at 5 months and become larger and more numerous by 10 months unlike in wild-type mice
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• at 3 months, anterograde transport of TH in the substantia nigra pars compacta neurons is impaired
• axonal transport is selectively impaired in the nigrostriatal system
• anterograde axonal transport of APP- and TH-containing vesicles and mitochondria is impaired
• anterograde transport in the sciatic nerve is impaired
• however, retrograde transport and transport of non-APP- and TH-containing vesicles and mitochondria are normal
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muscle
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• muscular atrophy begins at 4 weeks of age
• mice exhibit amyotrophy unlike wild-type mice
• however, no motor neuron degeneration is evident
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growth/size/body
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• female and male mice are lighter than wild-type mice by 30% and 27%, respectively
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homeostasis/metabolism