All Phenotypes Id1<tm1Xhsu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Id1^tm1Xhsu
targeted mutation 1, Xiao-Hong Sun
MGI:3831561

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Id1^tm1Xhsu/Id1^tm1Xhsu	B6.129X1-Id1^tm1Xhsu	MGI:3831663

Allelic Composition	Id1^tm1Xhsu/Id1^tm1Xhsu
Genetic Background	B6.129X1-Id1^tm1Xhsu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id1^tm1Xhsu mutation (1 available); any Id1 mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased hematopoietic stem cell number ( J:144696 )

• there is a 45% reduction in the number of long-term HSC in whole bone marrow cells based on the ability to generate multilineage engraftment after serial transplantation in irradiated hosts

• similar results are observed when fractions of bone marrow cells enriched in stem cells are used in serial transplantation of irradiated hosts

• multilineage engraftment in the primary bone marrow transplant is the same when mutant or wild-type mice are the donors, indicating short term HSC cells are unaffected

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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