Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Twist2tm1.1(cre)Dor mutation
(1 available);
any
Twist2 mutation
(10 available)
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normal phenotype
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• mice are viable and fertile and do not display any gross physical or behavioral abnormalities
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snai1tm1.1Stjw mutation
(0 available);
any
Snai1 mutation
(9 available)
Twist2tm1.1(cre)Dor mutation
(1 available);
any
Twist2 mutation
(10 available)
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normal phenotype
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• viable with no gross abnormalities at E14.5 and P1
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Defect in angioblast differentiation in Ptentm1Hwu/Ptentm1Hwu Kdrtm1Jrt/Kdr+ Twist2tm1.1(cre)Dor/Twist2+ mice
cardiovascular system
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• vasculogenesis defect
• impaired differentiation of angioblasts into mature endothelial cells and blood vessels
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respiratory system
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• increase in angioblasts in E18.5 lungs
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Increase in mesenchymal cell proliferation in Ptentm1Hwu/Ptentm1Hwu Twist2tm1.1(cre)Dor/Twist2+ mice
mortality/aging
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• lethality between E15.5 and E18.5
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• mutants with less severe phenotypes die within 2-3 hours of birth, displaying cyanosis, chest retractions, and dyspnea
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respiratory system
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• increase in collagen deposition in the lungs
• alveolar spaces are frequently lined by cuboidal cells with immature lamellar bodies
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• reduction in distal capillary network density in E15.5 lungs
• the capillary network is misaligned with corresponding respiratory airways (airway/capillary uncoupling or dysplasia) at E18.5
• increase in the distance between the capillaries and the lumen of the airways
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• marker analysis indicates expansion of the distal epithelial progenitor cell domain
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• E18.5 lungs exhibit a hypercellular mesenchymal compartment
• more than 5-fold increase in the number of CD45-CD31+ embryonic mesenchymal progenitor side population (E-SP) and CD45-CD31- E-SP cell populations in E17.5 lungs indicating an increase in lung mesenchymal progenitor cell populations
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• in mutants with less severe phenotypes that die within hours of birth
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cardiovascular system
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• reduction in distal capillary network density in E15.5 lungs
• the capillary network is misaligned with corresponding respiratory airways (airway/capillary uncoupling or dysplasia) at E18.5
• increase in the distance between the capillaries and the lumen of the airways
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• 44% of embryos lack of vascularization in entire embryos at E15.5
• E15.5 embryos show lack of vascularization in organs such as limbs and liver
• impaired differentiation of angioblasts into mature endothelial cells and blood vessels
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• 15% of embryos exhibit hemorrhage at E18.5
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homeostasis/metabolism
reproductive system
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• reduced cell proliferation in genital mesenchyme
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neoplasm
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• fewer smaller tumors induced by AOM/DSS
• however, development of induced colitis is normal
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homeostasis/metabolism
neoplasm
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• compared with Apcmin heterozygotes
• reduced proliferation and increased apoptosis of tumor cells compared with Apcmin heterozygotes
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• compared with Apcmin heterozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp14tm1Stjw mutation
(0 available);
any
Mmp14 mutation
(43 available)
Twist2tm1.1(cre)Dor mutation
(1 available);
any
Twist2 mutation
(10 available)
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mortality/aging
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• 31 of 34 mice die by 120 to 150 days with no mice surviving beyond 10 months
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skeleton
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N |
• mice exhibit normal osteoclast numbers
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• increased bone marrow adiposity
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• thickened articular cartilage
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• thickened articular cartilage
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• failure of suture closure
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growth/size/body
adipose tissue
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• increased bone marrow adiposity
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• adipocytes that localized to dermal fat pads fail to generate subcutaneous fat
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craniofacial
integument
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• adipocytes that localized to dermal fat pads fail to generate subcutaneous fat
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1.1Wesh mutation
(0 available);
any
Adam17 mutation
(62 available)
Tg(Scgb1a1-rtTA)2Jaw mutation
(1 available)
Tg(tetO-cre)1Jaw mutation
(5 available)
Twist2tm1.1(cre)Dor mutation
(1 available);
any
Twist2 mutation
(10 available)
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mortality/aging
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N |
• doxycycline-treated mice exhibit normal neonatal survival
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respiratory system
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• reduced pulmonary capillary formation in doxycycline-treated mice
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• doxycycline-treated mice exhibit enlarged airspaces with fewer number of saccules and reduced epithelial cell differentiation compared with control mice
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cellular
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• in the lungs of doxycycline-treated mice
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cardiovascular system
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• reduced pulmonary capillary formation in doxycycline-treated mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1.1Wesh mutation
(0 available);
any
Adam17 mutation
(62 available)
Twist2tm1.1(cre)Dor mutation
(1 available);
any
Twist2 mutation
(10 available)
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respiratory system
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N |
• mice exhibit normal lung development
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpratm1c(EUCOMM)Hmgu mutation
(0 available);
any
Ptpra mutation
(45 available)
Twist2tm1.1(cre)Dor mutation
(1 available);
any
Twist2 mutation
(10 available)
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Analysis Tools
